CuCl催化串联反应构建氢化异香豆素衍生物

Construction of hydroisocoumarin scaffold through CuCl-catalyzed cascade reaction

氢化异香豆素骨架化合物存在于很多天然产物和药物分子当中,是非常重要的活性骨架。本文以4-羟基-6-甲基-2-吡喃酮与邻羟基查尔酮为合成子,实现了含有氢化异香豆素骨架化合物的快速合成。

Hydroisocoumarin backbone represents a key structural motif in a wide range of natural products,and many of them possess important biological activities.A rapid synthesis of dihydroisocoumarins was achieved through the cascade reaction of 4-hydroxy-6-methyl-2-pyranone and ortho-hydroxychalcones.