2 179例晚期妊娠妇女生殖道B族链球菌筛查及耐药性分析

Analysis of prevalence and antibiotic resistanceof group B streptococcusin genital tract of women in late pregnancy in 2179 cases

目的分析晚期妊娠妇女生殖道B族链球菌(GBS)感染状况及耐药性情况,为临床用药提供参考。方法收集2018年1月至2020年12月就诊的妊娠35周及以上妇女生殖道分泌物标本进行细菌培养鉴定和药物敏感试验。结果2179例孕妇检出GBS 139株,检出率为6.38%。139株GBS药敏结果显示:未发现对青霉素、氨苄青霉素、利奈唑胺、奎奴普汀/达福普汀、万古霉素耐药株,对左氧氟沙星、红霉素、四环素、克林霉素的耐药率分别为:29.50%、77.70%、87.05%、90.65%。结论应重视晚期妊娠妇女GBS筛查,根据药敏试验结果合理选用抗菌药物进行预防治疗。

Objective To explore the prevalence and drug resistance of genital tract group B Streptococcu(GBS)infection in women in late pregnancy,and to provide a basis for clinical medication.Methods Genital tract secretions of women at 35 weeks of gestation and above were selected from January 2018 to December 2020 for bacterial culture identification and the drug resistance test.Results Among the 2179 specimens,a total of 139 were infected with GBS,with aprevalencerate of 6.38%.The results of drug susceptibility of 139 GBS strains showed that no strains were found to be resistant to penicillin,ampicillin,linezolid,quinuliptin/dafoptin and vancomycin,and the drug resistance rates to levofloxacin,erythromycin,tetracycline and clindamycin were 29.50%,77.70%,87.05%and 90.65%,respectively.Conclusion It is important to pay attention to the screening of GBS in women of late pregnancy and select antibiotics for preventive treatment according to the results of drug sensitivity test.