PM2.5对皮肤角质形成细胞的影响

Update on the effect of PM2.5 on skin keratinocytes

近年来我国空气中PM2.5污染严重,皮肤是人体抵御环境污染物的重要屏障,容易受到PM2.5的损害。角质形成细胞是皮肤表皮层的主要组成细胞,在皮肤天然免疫反应中发挥着关键作用。PM2.5作用于角质形成细胞,可引发多种生物学效应。本文综述了PM2.5对皮肤角质形成细胞增殖活性、细胞凋亡、细胞自噬、芳香烃受体激活、氧化应激、炎性反应及皮肤屏障相关成分表达改变等方面的影响,为进一步从机制上阐述PM2.5对人体皮肤的损害提供参考。

In recent years,the air pollution of PM2.5 in China was serious.Skin,as an important barrier against environmental pollutants,is easily damaged by PM2.5.Keratinocytes are the main constituent cells of the skin epidermis,which play a key role in the natural immune response of skin.PM2.5 can induce a variety of biological effects on keratinocytes.The effects of PM2.5 on skin keratinocyte proliferation activity,apoptosis,autophagy,aryl hydrocarbon receptor activation,oxidative stress,inflammatory response,and the expression of skin barrier related component are reviewed in this paper.It provides a reference for further study on the damage mechanism of PM2.5 to skin.