中药复方抗动脉粥样硬化作用机制的研究进展

Review of anti-atherosclerosis mechanism of a TCM formula

心血管疾病在全球的发病率和致死率仍居高不下,动脉粥样硬化(AS)是心血管疾病的重要病理基础,其致病机制至今尚未完全明确。目前主要认为,AS与血管内皮细胞损伤、脂质代谢紊乱、炎症反应、自噬和凋亡失衡等因素有关。传统中草药特别是中药复方在防治AS中取得良好疗效,对中药复方抗AS的药效及作用机制研究也越来越多。通过检索近5年的中药复方研究文献,综述中药复方抗AS作用机制,为抗AS中药复方的深入研究提供参考。

The global morbidity and mortality of cardiovascular diseases remain high.Atherosclerosis is an important pathological basis of cardiovascular diseases,and its pathogenic mechanism has not been fully clarified.It was reported that pathogenic mechanism of atherosclerosis is related to vascular endothelial cell injury,lipid metabolism disorder,inflammatory reaction,imbalance between autophagy and apoptosis,et al.Traditional Chinese medicine(TCM)formula has shown good effects in the prevention and treatment of atherosclerosis.There are a lot of studies that showed the anti-atherosclerosis effect and the mechanism of TCM formula.In this paper,we reviewed the mechanism of anti-atherosclerosis action of TCM formula by summarizing the research literatures in the past five years,and provide reference for the further systematic study of anti-atherosclerosis effect of TCM formula.