合并非酒精性脂肪性肝病的慢性乙型肝炎患者HBV复制与脂代谢的相互影响

Interaction between hepatitis B virus replication and lipid metabolism in patients with chronic hepatitis B and NAFLD

慢性HBV感染者人数依然庞大,严重危害国人健康。而随着生活方式的改变,我国非酒精性脂肪性肝病(NAFLD)的发病率呈现逐年升高的趋势。部分临床研究显示,HBV感染并存NAFLD的发生率相对较低,但也有NAFLD促进慢性乙型肝炎相关疾病进展的报道。通过文献检索及综述,探究合并NALFD的慢性乙型肝炎患者中HBV复制与脂代谢异常及脂肪肝发生的相互影响,以期为HBV抗病毒治疗及预防NAFLD的发生提供思路。

There is still a large number of patients with chronic hepatitis B virus(HBV)infection in China,which greatly affects the health of Chinese people.With the change in lifestyle,the incidence rate of nonalcoholic fatty liver disease(NAFLD)is increasing year by year in China.Some clinical studies have shown that there is a relatively low incidence rate of chronic HBV infection with NAFLD,while there are still reports on NAFLD in promoting the progression of chronic hepatitis B-related diseases.Based on literature search and review,this article attempts to investigate the interaction between HBV replication,abnormal lipid metabolism,and fatty liver disease in patients with chronic hepatitis B and NAFLD,in order to provide ideas for HBV antiviral treatment and prevention of NAFLD.