线粒体损伤在非酒精性脂肪性肝病发生发展中的作用

Role of mitochondrial injury in the development and progression of nonalcoholic fatty liver disease

线粒体是重要的细胞器,调节细胞脂质代谢、氧化磷酸化和ATP合成。线粒体生物合成障碍、稳态失衡乃至结构破坏都将导致脂质代谢紊乱以及氧化应激。非酒精性脂肪性肝病(NAFLD)是肝细胞脂质堆积为特征的慢性肝病。NAFLD是一个进展性疾病,表现为肝细胞脂肪变、脂肪性肝炎、肝纤维化和肝硬化这一轴向过程。目前认为线粒体在NAFLD发病中发挥着重要作用,NAFLD也被称为“线粒体病”。综述了脂质代谢障碍、氧化应激、线粒体稳态失衡等线粒体损伤与NAFLD发生发展的相关性。

Mitochondria are an important organelle and can regulate lipid metabolism,oxidative phosphorylation,and ATP synthesis.Disorder of mitochondria biosynthesis,loss of mitochondrial homeostasis,and even mitochondrial structural damage will lead to lipid metabolism disorders and oxidative stress.Nonalcoholic fatty liver disease(NAFLD)is a chronic liver disease characterized by lipid accumulation in hepatocytes.NAFLD is a progressive disease manifesting as the process from hepatocyte steatosis to steatohepatitis,liver fibrosis,and liver cirrhosis.It is currently believed that mitochondria play an important role in the onset of NAFLD,and thus NAFLD is also referred to as“mitochondrial disease”.This article reviews the association of mitochondrial injury,such as lipid metabolism disorders,change in reactive oxygen species,and loss of mitochondrial homeostasis,with the development and progression of NAFLD.