摘要
microRNA(miRNA)是一类小分子非编码RNA,转录后通过调控基因表达参与细胞增殖和凋亡等多个环节。目前越来越多的证据表明miRNA-122参与了多种肝病的发生、发展,通过查阅相关文献报道,总结了miRNA-122在非酒精性脂肪性肝病、肝炎、肝纤维化、肝癌等多种肝病中作用的研究进展,同时分析了miRNA-122作为一种新型无创的生物学标志物的潜能,为探索肝脏疾病诊疗提供参考。
MicroRNA is a type of small non-coding RNA that participates in multiple links such as cell proliferation and apoptosis by regulating gene expression after transcription.More and more studies have shown that microRNA-122(miRNA-122)is involved in the development and progression of a variety of liver diseases.With reference to related reports in the literature,this article summarizes advances in the role of miRNA-122 in various liver diseases including nonalcoholic fatty liver disease,hepatitis,liver fibrosis,and liver cancer and analyzes the potential of miRNA-122 as a new noninvasive biomarker,so as to provide a reference for exploring the diagnosis and treatment of liver disease.
作者
陈泽山
文彬
丘佩容
蓝红妮
黄宝特
邓鑫
CHEN Zeshan;WEN Bin;QIU Peirong;LAN Hongni;HUANG Baote;DENG Xin(Graduate School,Guangxi University of Chinese Medicine,Nanning 530001,China;Department of Infectious Diseases,Ruikang Hospital,Guangxi University of Chinese Medicine,Nanning 530001,China;Department of Science and Technology,Ruikang Hospital,Guangxi University of Chinese Medicine,Nanning 530001,China;Department of Gastroenterology,Ruikang Hospital,Guangxi University of Chinese Medicine,Nanning 530001,China;Department of Endocrinology,The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530001,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2021年第7期1724-1728,共5页
Journal of Clinical Hepatology
基金
国家自然科学基金(81860790)
广西自然科学基金项目(2017GXNSFAA198183)。
关键词
肝疾病
微RNAS
诊断
Liver Diseases
MicroRNAs
Diagnosis
