噻托溴铵辅助治疗对COPD急性加重期患者JAK/STAT通路蛋白及血气指标的影响

Effect of tiotropium bromide adjuvant therapy on JAK/STAT pathway protein and blood gas index in patients with acute exacerbation of COPD

目的探究噻托溴铵辅助治疗对慢性阻塞性肺疾病急性加重期(AECOPD)患者JAK/STAT通路蛋白表达及血气指标的影响。方法64例AECOPD患者随机均分为噻托溴铵组和常规组。常规组予以常规治疗,噻托溴铵组在常规组基础上予以噻托溴铵辅助治疗。观察并比较两组血气指标、JAK/STAT通路蛋白水平、肺功能以及不良反应情况。结果与治疗前比较,两组治疗后氧气分压、血氧饱和度、用力肺活量、一秒用力呼气容积及呼气峰值流速均升高(P<0.05),且噻托溴铵组升高更为显著(P<0.05)。与治疗前比较,两组二氧化碳分压和血清JAK1、JAK2、STAT1、STAT2相对表达量均降低(P<0.05),且噻托溴铵组降低更为显著(P<0.05)。治疗期间不良反应发生率噻托溴铵组与常规组比较差异无显著性(P>0.05)。结论噻托溴铵辅助治疗AECOPD患者可能通过抑制JAK/STAT通路蛋白,改善肺功能及血气指标,且安全性高。

Aim To investigate the effect of tiotropium bromide on JAK/STAT pathway protein and blood gas index in patients with chronic obstructive pulmonary disease(AECOPD).Methods 64 patients with AECOPD were randomly divided into tiotropium group and conventional group.The conventional group was given routine treatment,and the tiotropium group was treated with the aid of tiotropium on the basis of the conventional group.The blood gas index,JAK/STAT pathway protein level,lung function and adverse reactions were observed and compared.Results Compared with the pre-treatment,the two groups increased the partial pressure of PO2,SaO2,FVC,FEV1 and PEF(P<0.05),and the increase of tiotropium group was more significant(P<0.05).Compared with the pre-treatment,the relative expression of the two groups of PCO2 and serum JAK1,JAK2,STAT1 and STAT2 decreased(P<0.05),and the decrease of tiotropium group was more significant(P<0.05).There was no significant difference between the tiotropium group and the conventional group(P>0.05).Conclusion The treatment of AECOPD patients with tiotropium may improve lung function and blood gas index by inhibiting JAK/STAT pathway protein expression,and it is safe.