精神分裂症患者采用甲磺酸齐拉西酮治疗的临床效果分析

Clinical analysis of treatment with zilasidone mesylate in schizophrenia

目的探究精神分裂症患者采用甲磺酸齐拉西酮治疗的临床效果。方法选取本院2019年2—12月收治的75例精神分裂症患者作为研究对象,采用随机数字表法分为对照组(n=36)及实验组(n=39)。对照组给予奥氮平治疗,实验组在对照组基础上给予甲磺酸齐拉西酮治疗。比较两组实验室各项指标及PANSS评分、BMI。结果治疗12周后,两组BDNF、NGF均高于治疗前,且实验组高于对照组,FPG高于治疗前,但实验组低于对照组,差异有统计学意义(P<0.05)。治疗12周后,两组PANSS评分均低于治疗前,且实验组低于对照组;两组BMI均高于治疗前,且实验组高于对照组,差异有统计学意义(P<0.05)。结论精神分裂症患者采用甲磺酸齐拉西酮治疗的临床效果理想,可有效抑制病情进展,改善临床症状,值得深入研究。

Objective To investigate the clinical effect of zilacetone mesylate in schizophrenia.Methods 75 patients with schizophrenia received from February 2019 to December 2019 were selected as reseach subjects,they were randomly divided into control group(n=36)and experimental group(n=39).The control group was treated with olanzapine,the experimental group was treated with zilacetone mesylate on the basis of the control group.The laboratory indexes and PANSS scores and BMI were compared between the two groups.Results After 12 weeks of treatment,both groups BDNF,NGF were higher than before treatment,and the experimental group was higher than the control group,FPG higher than before treatment,but the experimental group was lower than the control group,the difference was statistically significant(P<0.05).After 12 weeks of treatment,both groups had lower PANSS scores than before treatment,the experimental group was lower than the control group;both groups BMI were higher than before treatment,and the experimental group was higher than the control group,the difference was statistically significant(P<0.05).Conclusion The clinical effect of zilacetone mesylate in schizophrenia is ideal,can effectively inhibit the progression of the disease,Improve clinical symptoms,worthy of further study.