应用利格列汀治疗2型糖尿病患者的临床疗效研究

Study on the clinical efficacy of linagliptin in the treatment of type 2 diabetes

目的探究采用利格列汀治疗2型糖尿病患者的临床效果。方法选取本院2018年12月至2019年10月收治的2型糖尿病患者60例,按照治疗方式的不同分为观察组与对照组,各30例。对照组采用重组甘精胰岛+重组人胰岛素治疗,观察组在对照组基础上联合利格列汀治疗,比较两组治疗前后空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)及体重指数(BMI)、胰岛素抵抗指数(HOMAIR)、胰岛β细胞功能指数(HOMA-β)和不良反应发生率。结果治疗前,两组FBG、2 h PG、HbA1c及BMI、HOMA-IR、HOMA-β指标比较差异无统计学意义;治疗后,两组上述指标均得到一定改善,且观察组FBG、2 h PG、HbA1c及BMI、HOMA-IR、HOMA-β指标改善程度明显优于对照组,差异有统计学意义(P<0.05)。治疗后,观察组不良反应发生率为10.00%,低于对照组的33.33%(P<0.05)。结论利格列汀治疗2型糖尿病患者可改善患者的血糖水平、体重指数,保护胰岛健康,安全性较高,效果突出,值得临床推广应用。

Objective To explore the clinical effect of linagliptin in the treatment of patients with type 2 diabetes.Methods A total of 60 patients with type 2 diabetes who were admitted to our hospital from December 2018 to October 2019 were selected and they were divided into observation group and control group according to different treatment methods,with 30 cases in each group.The control group was treated with recombinant glomerine pancreatic islets+recombinant human insulin,and the observation group was treated with linagliptin on the basis of the control group.The fasting blood glucose(FBG)before and after treatment,and 2 h blood glucose(2 h PG)after meals,glycosylated hemoglobin(HbA1c)and body mass index(BMI),insulin resistance index(HOMA-IR),pancreaticβcell function index(HOMA-β)and adverse reactions were compared between two groups.Results Before treatment,there was no significant difference in FBG,2 h PG,HbA1c and BMI,HOMA-IR,and HOMA-βindexes between the two groups.After treatment,the above indexes of the two groups were improved to some extent,and the observation group FBG,2 h PG,HbA1 c and BMI,HOMA-IR,HOMA-βindex improvement degree was significantly better than the control group,the difference was statistically significant(P<0.05).After treatment,the incidence of adverse reactions in the observation group was 10.00%,which was lower than 33.33%in the control group(P<0.05).Conclusion Linagliptin can improve the blood glucose level and BMI of patients with type 2 diabetes,and protect the health of islets.It has high safety and outstanding effect,and it is worthy of clinical application.