雌二醇片/雌二醇地屈孕酮片复合包装治疗卵巢功能下降及卵巢早衰患者的临床观察

Clinical observation on the treatment of ovarian dysfunction and premature ovarian failure with fenmatong

目的探究雌二醇片/雌二醇地屈孕酮片复合包装治疗卵巢功能下降及卵巢早衰患者的效果。方法选取2018年4月至2019年10月本院收治的64例卵巢功能下降及卵巢早衰患者作为研究对象,随机分为对照组与实验组,各32例。对照组应用常规激素替代治疗,实验组应用雌二醇片/雌二醇地屈孕酮片复合包装治疗。比较两组患者血清性激素水平、总有效率及血脂水平。结果实验组总有效率为90.63%,高于对照组的68.75%,差异有统计学意义(P<0.05);治疗后,实验组卵泡刺激素、促黄体生成素水平低于对照组,且雌二醇水平高于对照组,差异均有统计学意义(P<0.05);治疗后,实验组甘油三酯、总胆固醇及低密度脂蛋白胆固醇水平低于对照组,且高密度脂蛋白胆固醇水平高于对照组,差异均有统计学意义(P<0.05)。结论雌二醇片/雌二醇地屈孕酮片复合包装治疗卵巢功能下降及卵巢早衰患者效果显著,有助于改善血清性激素水平,并可在一定程度上降低血脂水平。

Objective To explore the effect of fenmatong in the treatment of ovarian dysfunction and premature ovarian failure.Methods From April 2018 to October 2019,64 patients with ovarian dysfunction and premature ovarian failure admitted in our hospital were selected as reseach subjects and they were randomly divided into control group and experimental group,with 32 cases in each group.The control group was treated with conventional hormone replacement therapy,and the experimental group wastreated with fenmatong therapy.The serum sex hormone level,total effective rate and blood lipid level were compared between the two groups.Results The total effective rate of the experimental group was 90.63%,which was higher than 68.75%of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of follicle stimulating hormone and luteinizing hormone in the experimental group were lower than those in the control group,and the level of estradiol was higher than that in the control group,the difference was statistically significant(P<0.05);after treatment,the levels of triglycerides,total cholesterol and lowdensity lipoprotein cholesterol in the experimental group were lower than those in the control group,and the levels of high-density lipoprotein cholesterol were higher than those in the control group,the difference was statistically significant(P<0.05).Conclusion Fenmatong is effective in the treatment of ovarian dysfunction and premature ovarian failure,it is helpful to improve the level of serum sex hormone,and reduce the level of blood lipid to some extent.