糖尿病患者内脏脂肪面积与血清CA19-9的相关性

Correlation between visceral fat area and serum CA19-9 in patients with diabetes mellitus

目的测定内脏脂肪面积,探讨血清糖类抗原(CA)19-9与内脏脂肪面积(VFA)的相关性。方法选取2014年7月至2019年5月于西南医科大学附属医院就诊的2型糖尿病(T2DM)患者312例,分为CA19-9≤30 u/ml组(n=236)和CA19-9>30 u/ml组(n=76),分别统计分析两组性别、年龄、空腹血糖、舒张压、收缩压、身高、体重、BMI、头围、颈围、腰围、臀围、VFA、皮下脂肪面积、高血压病史、高脂血症病史、抽烟史、饮酒史、空腹C肽、120 min C肽、糖化血红蛋白(HbA1c)、ALT、AST、ALP、γ-GT、BUN、Cr、TG、TC、HDL-C、LDL-C、CEA、CA19-9等相关指标。结果BMI、血糖、VFA为CA19-9的独立影响因素(P<0.05)。VFA与CA19-9呈正相关关系,且具有统计学意义(P<0.05)。结论糖尿病患者在较高的血糖及VFA水平时,可同时伴有较高的血清CA19-9水平。

Objective To investigate the correlation between serum carbohydrate antigen(CA)19-9 and visceral fat area(VFA)in the patients with type 2 diabetes mellitus(T2 DM).Methods A total of 312 T2 DM patients who received treatment at Affiliated Hospital of Southwest Medical University from July 2014 to May 2019 were selected and divided into CA19-9≤30 u/ml group(n=236)and CA19-9>30 u/ml group(n=76).The following indicators were measured and analyzed in two groups,including gender,age,fasting blood glucose,diastolic blood pressure(DBP),systolic blood pressure(SBP),height,weight,BMI,head,neck,waist and hip circumference,VFA,subcutaneous fat area(SFA),history of hypertension,hyperlipidemia history,smoking history,drinking history,fasting C-peptide,120-minute C-peptide values,levels of HbA1 c,ALT,AST,alkaline phosphatase(ALP),gamma glutamyltransferase(γ-GT),blood urea nitrogen(BUN),uric acid(UA),creatinine(CR),TG,TC,HDL-C,LDL-C,hsCRP,CEA,CA19-9 and other related indicators.Results Logistic regression analysis showed that BMI,blood glucose,and VFA were independent influencing factors of elevated CA19-9(P<0.05).The VFA was positively correlated with CA19-9(P<0.05).Conclusion T2 DM patients with higher blood glucose and VFA levels can be accompanied by higher serum CA19-9 levels.