基础LH/FSH比值对多囊卵巢综合征患者IVF-ET妊娠结局的影响

Effect of basal LH/FSH ratio on pregnancy outcome of patients with PCOS undergoing IVF-ET

目的探讨基础促黄体生成素/卵泡刺激素(LH/FSH)比值对多囊卵巢综合征(PCOS)患者体外受精-胚胎移植(IVF-ET)妊娠结局的影响。方法回顾性分析2018年6月至2020年6月于山东中医药大学附属医院生殖中心采用促性腺激素释放激素(GnRH)拮抗剂方案行IVF-ET治疗的PCOS患者,根据基础LH/FSH比值将136例患者分为LH/FSH<1组(A组)、1≤LH/FSH<2组(B组)和LH/FSH≥2组(C组),探讨三组患者不同基础LH/FSH比值对超促排卵用药、胚胎实验室结果及妊娠结局的影响。结果三组BMI、促性腺激素(Gn)总用量比较差异有统计学意义(P<0.01),A组>B组>C组。三组患者获卵数、受精率、优质胚胎率、临床妊娠率比较差异无统计学意义(P>0.05)。结论PCOS患者的BMI以及应用GnRH拮抗剂方案的Gn总用量随着LH/FSH比值降低而升高,LH/FSH比值较低的PCOS患者有获得更佳IVF-ET临床结局的趋势。

Objective To investigate the effect of basal luteinizing hormone(LH)/follicle-stimulating hormone(FSH)ratio on pregnancy outcomes of patients with polycystic ovary syndrome(PCOS)undergoing in vitro fertilization-embryo transfer(IVF-ET).Methods A total of 136 PCOS patients received IVF-ET with gonadotropin-releasing hormone(GnRH)antagonist protocol at Affiliated Hospital of Shandong University of Chinese Medicine from June 2018 to June 2020 were analyzed retrospectively.According to the basal LH/FSH ratio,the patients were divided into group A(LH/FSH<1),group B(1≤LH/FSH<2)and group C(LH/FSH≥2).The influences of different basal LH/FSH ratio on ovulation induction drugs,laboratory results of embryo and pregnancy outcome were analyzed in three groups.Results There were significant differences in BMI and total dosage of gonadotropin(Gn)among three groups(group A>group B>group C,P<0.01).There was no significant difference in the number of eggs retrieved,fertilization rate,high-quality embryo rate and clinical pregnancy rate among the three groups(P>0.05).Conclusion With the decrease of LH/FSH ratio in PCOS patients,BMI and Gn dosage increased,and the patients with lower LH/FSH ratio tend to achieve better clinical outcomes of IVF-ET treatment.