小剂量阿司匹林辅助治疗重度妊娠期高血压患者的效果及其对凝血功能、ET-1及NO水平的影响

Effects of low-dose aspirin in the adjuvant treatment of pregnant patients with severe hypertension and its influence on patients’ coagulation function,ET-1 and NO levels

目的:探究小剂量阿司匹林辅助治疗重度妊娠期高血压患者的效果及其对凝血功能、ET-1及NO水平的影响。方法:选取113例重度妊娠期高血压患者作为研究对象,随机分为两组。对照组56例给予静脉注射拉贝洛尔,观察组57例增加小剂量阿司匹林治疗,分析两组患者临床疗效、凝血功能及血管内皮功能。结果:观察组临床疗效、凝血功能及血管内皮功能均明显优于对照组(P<0.05)。结论:使用小剂量阿司匹林辅助治疗重度妊娠期高血压患者效果明显,能够通过阻断血栓素A2合成、抑制内皮细胞的环氧化酶活性等机制,改善凝血功能和血管内皮功能。

Objective: To investigate the effects of low-dose aspirin in the adjuvant treatment of pregnant patients with severe gestational hypertension and its effects on patients’ blood coagulation function, ET-1 and NO levels. Methods: 113 cases of severe gestational hypertension patients were randomized into 2 groups, 56 cases in the control group received intravenous injection of labetalol, while another 57 cases were treated with low-dose aspirin. Then, the clinical efficacy, coagulation function and vascular endothelial function in patients were compared between the 2 groups. Results: The clinical efficacy, coagulation function and vascular endothelial function of the observation group was significantly better than that of the control group(P<0.05). Conclusion: The adjunctive treatment of low-dose aspirin has obvious curative effect on patients with severe gestational hypertension. It can improve the coagulation function and vascular endothelial function by blocking the synthesis of thromboxane A2 and inhibiting the coxidase activity of endothelial cells.