拉莫三嗪联合丙戊酸钠治疗中风后癫痫患者的效果观察

Clinical efficacy of lamotrigine combined with sodium valproate in the treatment of patients with epilepsy after a stroke

目的:探讨拉莫三嗪联合丙戊酸钠治疗中风后癫痫的临床效果。方法:选取82例中风后癫痫患者,按照随机数字表法分为两组,每组各41例。对照组予以丙戊酸钠治疗,观察组在对照组的基础上加用拉莫三嗪治疗。比较两组临床疗效、癫痫发作状况、神经功能和不良反应。结果:观察组治疗总有效率高于对照组,两组比较差异有统计学意义(P<0.05);观察组癫痫发作次数少于对照组,发作持续时间短于对照组,两组比较差异有统计学意义(P<0.05);观察组NIHSS评分低于对照组(P<0.05);两组均仅发生轻微少量不良反应,无需特殊处理。结论:拉莫三嗪联合丙戊酸钠治疗中风后癫痫患者,可提高临床疗效,减少癫痫发作次数,改善神经功能。

Objective:To investigate the clinical efficacy of lamotrigine combined with sodium valproate in the treatment of patients with epilepsy after stroke.Methods:82 cases of post-stroke epilepsy patients were randomized into two groups,with 41 cases in each group.The control group were treated with valproate sodium,while the observation group were additionally treated with lamotrigine on basis of the treatment for the control group.The clinical efficacy,seizure,the neurological function and incidence of adverse reactions of patients were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group,which was of statistical difference(P<0.05);the frequency of seizure in the observation group was less than that in the control group,and the duration of seizure was shorter than that in the control group,and the difference between the two groups was statistically significant(P<0.05);NIHSS score was lower than that of the control group(P<0.05);there were only a small amount of adverse reactions occurred in both groups and no special treatment was required(P<0.05).Conclusion:Lamotrigine combined with sodium valproate can improve the therapeutic effects of post-stroke epilepsy,reduce seizures and improve neurological function of patients.