特布他林对老年AECOPD肺部感染患者肺功能及HIF1、γ-GCS水平的影响

Effects of terbutaline on lung function,HIF1 andγ-GCS levels in elderly AECOPD patients with lung infection

目的:探讨特布他林对老年慢阻肺急性加重期(AECOPD)肺部感染患者肺功能及HIF1、γ-GCS水平的影响。方法:选取125例老年慢阻肺急性加重期肺部感染患者作为研究对象,按照随机数字表法分为对照组62例和观察组63例。对照组给予茶碱缓释片联合噻托溴铵粉吸入剂治疗,观察组在对照组的基础上予以特布他林治疗,治疗2个月后,对比两组患者临床疗效、肺功能、基质金属蛋白酶-9(MMP-9)、白介素-8(IL-8)、低氧诱导因子1(HIF1)、γ-谷氨酰半胱氨酸合酶(γ-GCS)水平及不良反应。结果:治疗后,观察组临床疗效优于对照组(P<0.05);观察组肺功能指标用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、(FEV1/FVC)水平高于对照组(P<0.05);观察组MMP-9、IL-8、HIF1、γ-GCS水平低于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:特布他林应用于老年AECOPD肺部感染患者中,可以提高患者肺功能,降低患者MMP-9、IL-8、HIF1、γ-GCS水平,疗效显著,且不增加不良反应的发生率。

Objective:To investigate the effects of terbutaline on lung function,HIF1 andγ-GCS levels in elderly patients with an exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with lung infection.Methods:125 elderly AECOPD patients with lung infection were selected and randomized into the control group(n=62)and the observation group(n=63).The control group were given theophylline sustained-release tablets combined with tiotropium bromide powder inhalation,while the observation group were given terbutaline on the basis of treatment for the control group.After two months of treatment,the clinical efficacy,lung function,matrix metalloproteinase-9(MMP-9),interleukin-8(IL-8),hypoxia inducible factor 1(HIF1),γ-glutamylcysteine synthase(γ-GCS)and adverse reactions were compared between the two groups.Results:After treatment,the clinical efficacy of the observation group was better than that of the control group(P<0.05);the lung function levels of forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),and ratio of FEV1 and FVC(FEV1/FVC)were higher than those of the control group(P<0.05);the levels of MMP-9,IL-8,HIF1,andγ-GCS in the observation group were lower than those in the control group(P<0.05);and there was no significant difference in the incidence of adverse reactions between both groups(P>0.05).Conclusion:The application of terbutaline to elderly patients with AECOPD can improve the lung function of the patients,reduce the levels of MMP-9,IL-8,HIF1 andγ-GCS,thereby it can effectively improve the clinical treatment efficacy without increasing the incidence of adverse reactions.