左侧颞叶癫痫患者静息态脑网络间功能连接改变研究

Study of The Changes of Functional Connections Between Brain Networks in Patients with Left Medial Temporal Lobe Epilepsy in Resting State

目的探讨在静息状态下,左侧内侧颞叶癫痫(Left Medial Temporal Lobe Epilepsy,LMTLE)患者脑网络间的功能连接情况。方法选取经病理证实的19名LMTLE患者及20名健康志愿者作为正常对照组。进行rs-fMRI检查,采用独立成分分析并提取脑网络,比较患者组与正常对照组的网络间功能连接强度的差异,分析有组间差异的静息态脑网络的连接情况。结果与正常对照组比较,LMTLE组CEN-aDMN正向功能连接明显增加,差异有统计学意义(P<0.05)。结论LMTLE患者的CEN-aDMN网络间功能连接增加与可能与脑网络重塑有关。

Objective To investigate the changes of functional connections between brain networks in patients with left medial temporal lobe epilepsy(LMTLE)in resting state.Methods Nineteen patients with LMTLE confirmed by pathology and 20 healthy volunteers were selected as normal control group.After rs-fMRI examination and extraction of resting-state networks(RSNs),the differences in functional connectivity(FC)strength of RSNs between the patient group and the normal control group were compared,and the connectivity of RSNs with differences between the groups was analyzed.Results Compared with normal control group,positive functional connectivity of CEN-aDMN was significantly increased in LMTLE group,and the difference was statistically significant(P<0.05).Conclusion The increase of FC in CEN-aDMN networks in LMTLE patients is associated with cognitive dysfunction.