lncRNAH19参与Ⅱ型糖尿病发生发展相关分子机制的研究进展

Research progress on molecular mechanism of lncRNAH19 involved in occurrence and development of type Ⅱ diabetes mellitus

长链非编码RNA(lncRNA)是目前发现的一类长度超过200个核苷酸且不具有编码蛋白质能力的RNA,为RNA聚合酶Ⅱ转录得到的副产物。近年来,越来越多的研究发现lncRNA可以通过调节细胞的增殖、分化和凋亡,参与糖尿病、心血管疾病以及多种退行性疾病的发生发展过程。作为人类最早被鉴定的lncRNA分子,研究发现H19可以干扰机体糖脂代谢平衡,与Ⅱ型糖尿病(T2DM)及其并发症的发生密切相关,成为T2DM研究的新热点。本文介绍了H19参与T2DM及其并发症发生过程的作用靶点,简述了H19发挥的功能以及相关分子机制,并指出今后进一步的研究方向。

Long noncoding RNA(lncRNA) is a transcription by-product of RNA polymerase II, comprising more than 200 nucleotide in the absence of the ability to encode proteins. In recent years, more and more studies have found that lncRNA can be involved in the occurrence and development of diabetes, cardiovascular diseases, and a variety of degenerative diseases by regulating cell proliferation, differentiation, and apoptosis. As the first identified lncRNA molecule, H19 has been found to interfere with glucose and lipid metabolism balance, and is closely related to Type II diabetes mellitus(T2DM) and its complications, making it a new hot spot in T2 DM research. The review introduced identified targets of H19 involved in the process of T2DM and its complications, briefly described the functions and related molecular mechanisms of H19, and proposed future research directions.