海马区保护性全脑放疗研究进展

Research progress on hippocampal-avoidance whole brain radiotherapy

随着影像诊断的提高和现代放疗新技术的发展,肿瘤患者的生存期延长,肿瘤脑转移(BM)的发生率明显增高,患者生活质量及潜在放疗相关的神经认知功能损伤逐渐受到重视。全脑放疗(WBRT)作为BM患者常见的局部治疗手段之一,因其放疗后引起的神经认知功能障碍而备受争议,而海马区转移瘤的发生率及该部位放疗受损所引起的神经认知功能障碍推动了海马保护性WBRT(HA-WBRT)新技术的开展。本文将讨论HA-WBRT的可行性并总结近年来研究进展。

With the advancement of imaging diagnosis and the development of modern radiotherapy,the survival of cancer patients has been prolonged and the incidence rate of brain metastases(BM)has been significantly increased.The quality of life of patients and potential radiotherapy-induced neurocognitive impairment have gradually captivated widespread attention.Whole brain radiotherapy(WBRT)is one of the common local therapies for BM patients.However,the application of WBRT is controversial because it may lead to neurocognitive impairment.The incidence of metastatic tumors in hippocampus and radiation-induced neurocognitive impairment can accelerate the implementation of hippocampal-avoidance WBRT(HA-WBRT).In this article,the feasibility of HA-WBRT was discussed and research progress in recent years was reviewed.