基于低频振幅分数和度中心性的躯体症状障碍静息态回行功能成像研究

Resting state functional magnetic resonance imaging of somatic symptom disorder based on fALFF and DC

目的运用静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)并结合低频振幅分数(fractional amplitude of low-frequency fluctation,fALFF)和度中心性(degree centrality,DC)来探讨躯体症状障碍(somatic symptom disorder,SSD)患者是否存在某些脑功能上的异常,从而为躯体症状障碍的临床诊疗提供参考信息。材料与方法45例右利手SSD患者和43名右利手健康对照组参与静息态磁共振扫描,fALFF和DC分析探测SSD患者静息态下自发性脑活动上的特征。SPM12软件用于磁共振数据的分析,组分析采用双样本t检验fALFF和DC统计阈值为体素水平P<0.001,团块水平经过family wise error(FWE)校正,P<0.05,且大于10个体素的团块将被报道。结果静息态脑功能结果显示SSD患者在边缘叶、丘脑处(t=4.91)fALFF值显著高于健康对照组。SSD患者在额叶、扣带回(t=5.20)的DC值显著低于健康对照组。结论这些异常的区域可能与SSD的发病机理有关,这些区域的功能异常可能会导致个体情绪处理、自我感觉和身体知觉功能的异常。

Objective:Using resting-state functional magnetic resonance image(rs-fMRI)combined with fractional amplitude of low-frequency fluctation(fALFF)and degree centrality(DC)to explore the change of brain function in patients with somatic symptom disorder(SSD),so that it will provide reference information for clinical treatment.Materials and Methods:Forty five right-handed patients with somatic symptoms disorder and 43 right-handed healthy controls participated in rs-fMRI scanning.ALFF and DC analysis were used to detect the characteristics of spontaneous brain activity in SSD patients at resting-state.SPM 12 software was used to analyze fMRI data.The statistical threshold of fALFF and DC was voxel level(P<0.001)by two sample t-test.The cluster level was corrected by family wise error(FWE),P<0.05.When the cluster more than 10 voxels was reported.Results:Patients with SSD showed increased fALFF values in limbic lobe,and thalamus compared with HCs.Besides,atients wit SSD showed decreased DC values in frontal lobe,cingulate gyrus.Conclusions:These dysfunction areas seem to have a particular importance for the occurrence of SSD,which may result in dysfunction in emotional processing,interoception,and body perception.