摘要
目的运用静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)并结合低频振幅分数(fractional amplitude of low-frequency fluctation,fALFF)和度中心性(degree centrality,DC)来探讨躯体症状障碍(somatic symptom disorder,SSD)患者是否存在某些脑功能上的异常,从而为躯体症状障碍的临床诊疗提供参考信息。材料与方法45例右利手SSD患者和43名右利手健康对照组参与静息态磁共振扫描,fALFF和DC分析探测SSD患者静息态下自发性脑活动上的特征。SPM12软件用于磁共振数据的分析,组分析采用双样本t检验fALFF和DC统计阈值为体素水平P<0.001,团块水平经过family wise error(FWE)校正,P<0.05,且大于10个体素的团块将被报道。结果静息态脑功能结果显示SSD患者在边缘叶、丘脑处(t=4.91)fALFF值显著高于健康对照组。SSD患者在额叶、扣带回(t=5.20)的DC值显著低于健康对照组。结论这些异常的区域可能与SSD的发病机理有关,这些区域的功能异常可能会导致个体情绪处理、自我感觉和身体知觉功能的异常。
Objective:Using resting-state functional magnetic resonance image(rs-fMRI)combined with fractional amplitude of low-frequency fluctation(fALFF)and degree centrality(DC)to explore the change of brain function in patients with somatic symptom disorder(SSD),so that it will provide reference information for clinical treatment.Materials and Methods:Forty five right-handed patients with somatic symptoms disorder and 43 right-handed healthy controls participated in rs-fMRI scanning.ALFF and DC analysis were used to detect the characteristics of spontaneous brain activity in SSD patients at resting-state.SPM 12 software was used to analyze fMRI data.The statistical threshold of fALFF and DC was voxel level(P<0.001)by two sample t-test.The cluster level was corrected by family wise error(FWE),P<0.05.When the cluster more than 10 voxels was reported.Results:Patients with SSD showed increased fALFF values in limbic lobe,and thalamus compared with HCs.Besides,atients wit SSD showed decreased DC values in frontal lobe,cingulate gyrus.Conclusions:These dysfunction areas seem to have a particular importance for the occurrence of SSD,which may result in dysfunction in emotional processing,interoception,and body perception.
作者
崔阳阳
梁怀彬
朱千
汤伟
高婷婷
刘建仁
杜小霞
CUI Yangyang;LIANG Huaibin;ZHU Qian;TANG Wei;GAO Tingting;LIU Jianren;DU Xiaoxia(Shanghai Key Laboratory of Magnetic Resonance&Department of Physics,,School of physics and electronics,East China Normal University,Shanghai 200062,China;Department of Neurology,Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2021年第7期51-54,共4页
Chinese Journal of Magnetic Resonance Imaging
基金
国家自然科学基金(编号:81571658)。
关键词
躯体化症状障碍
低频振幅分数
度中心性
功能磁共振成像
somatic symptom disorder
fractional amplitude of low-frequency fluctation
degree centrality
functional magnetic resonance image