临床药师参与1例坏死性筋膜炎患者抗感染治疗分析

Analysis of clinical pharmacist participating in the anti-infective treatment for a patient with necrotizing fasciitis

临床药师通过对1例坏死性筋膜炎患者抗感染治疗的分析,发现初始治疗方案替加环素联合亚胺培南西司他丁钠治疗效果不佳,协助医师调整优化治疗方案。在治疗重症皮肤软组织感染中,虽然替加环素可用于复杂皮肤软组织感染,但是该患者临床治疗效果不佳。患者分泌物培养是化脓性链球菌,即使是重症的皮肤软组织感染,青霉素对化脓性链球菌的临床疗效较好。临床药师利用自己掌握的药学知识,与医师共同制定了安全、经济、有效的抗感染方案,取得了良好的临床疗效。

Clinical pharmacists analyzed the anti-infective treatment for a patient with necrotizing fasciitis and found that the initial treatment regimen-tigecycline combined with imipenem cilastatin sodium was not effective.In the treatment of severe skin and soft tissue infections,although tigecycline can be used for complex skin and soft tissue infections,the clinical treatment effect of this patient was not good.The patient′s secretion culture showed it was Streptococcus pyogenes.Even with severe skin and soft tissue infections,penicillin has a better clinical effect on Streptococcus pyogenes.The clinical pharmacists used their pharmacological knowledge and work with the physicians to make a safe,economical and effective anti-infection plan,which has achieved good clinical efficacy.