摘要
P2X7受体是以三磷酸腺苷(ATP)为配体的离子通道型受体,在多种免疫细胞和组织中广泛表达,其激活后可参与多种生理和病理过程。P2X7受体在结肠癌中异常表达,并在结肠癌的进展中发挥抑癌和促癌双重作用。P2X7受体被细胞外的ATP激活后,可通过多种机制有效抑制结肠癌细胞的增殖,并诱导细胞凋亡。另外,P2X7受体还能促进结肠癌的生长、侵袭和转移。了解P2X7受体的激活及其效应机制对于结肠癌的治疗具有重要意义。
P2X7 receptor is an ion channel receptor with adenosine triphosphate(ATP)as its ligand,which is widely expressed in various immune cells and tissues.Activated P2X7 receptor is involved in a variety of physiological and pathological processes.P2X7 receptor is abnormally expressed in colon cancer,and plays a duel role of cancer-promoting and cancer-suppressing in colon cancer progression.When P2X7 receptor is activated by extracellular ATP,it can effectively inhibit proliferation and induce apoptosis of colon cancer cells through various mechanisms.In addition,P2X7 receptor can also promote the growth,invasion and metastasis of colon cancer.Understanding the activation of P2X7 receptor and its effect mechanism is of great significance for the treatment of colon cancer.
作者
李倩倩
朱晓娣
赵荣兰
彭效祥
Li Qianqian;Zhu Xiaodi;Zhao Ronglan;Peng Xiaoxiang(Institute of Nanomedical Technology,School of Laboratory Medicine,Weifang Medical University&Key Laboratory of Clinical Laboratory Diagnostics,12th 5-Year Project of Shandong Province,Weifang Medical University,Weifang 261053,China)
出处
《国际肿瘤学杂志》
CAS
2021年第4期250-253,共4页
Journal of International Oncology
基金
国家自然科学基金(81770915、81301737)。
关键词
受体
嘌呤能P2X7
结肠肿瘤
三磷酸腺苷
Receptors,purinergic P2X7
Colonic neoplasms
Adenosine triphosphate
