肌少症影响因素Meta分析

Influencing factors for sarcopenia: A Meta-analysis

目的通过Meta分析系统评价肌少症的影响因素,为该病的预防提供循证依据。方法计算机检索中国知网(CNKI)、万方数据库(WanFang Data)、维普中文期刊数据库(VIP)、中国生物医学文献数据库(SinoMed)、PubMed、Embase、Web of science和Cochrane图书馆,收集文献时间为各数据库建库至2020年10月,文献研究类型包括队列研究、病例对照研究和横断面研究,根据文献纳入与排除标准筛选出合格的文献,运用RevMan 5.3软件进行Meta分析。结果 31篇文献符合纳入标准,累计病例组8 011例,对照组27 311例,经Meta分析结果显示,肌少症的影响因素为:年龄(OR=1.17,95%CI:1.12~1.22)、年龄>70岁(OR=3.35,95%CI:1.96~5.71)、BMI<18.5 kg/m^(2)(OR=4.32,95%CI:2.97~6.29)、性别(OR=1.83,95%CI:1.18~2.84)、低体育锻炼(OR=2.25,95%CI:1.65~3.07)、糖尿病(OR=2.29,95%CI:1.32~3.97)、吸烟(OR=3.53,95%CI:2.28~5.47)、营养不良(OR=4.04,95%CI:2.13~7.68)、体脂率(OR=1.21,95%CI:1.15~1.25)和低教育水平(OR=1.24,95%CI:1.05~1.47)。结论年龄、年龄>70岁、BMI<18.5 kg/m^(2)、性别、低体育锻炼、糖尿病、吸烟、营养不良、体脂率、低教育水平是肌少症的影响因素。临床医护人员应着重对涉及肌少症影响因素的人群及早进行干预。

Objective To comprehensively address the influencing factors for sarcopenia through Meta-analysis and to provide evidence for disease prevention. Methods A systematic review was conducted on literatures retrieved from a variety of databases as China Knowledge Network(CNKI), WanFang Data, VIP Chinese Journal Database(VIP), Chinese Biomedical Literature Database(SinoMed), PubMed, Embase, Web of Science and Cochrane Library based on exclusion and inclusion criteria, which included cohort studies, case-control studies and cross-sectional studies up until October 2020.RevMan 5.3 software was used for meta analysis. Results A total of 31 literatures were included in the analysis, 8 011 were cases and 27 311 were controls.The meta-analysis showed that the influencing factors for sarcopenia were age(OR=1.17, 95%CI: 1.12-1.22), Age >70(OR=3.35, 95%CI: 1.96-5.71), BMI<18.5 kg/m^(2)(OR=4.32,95%CI: 2.97-6.29), gender(OR=1.83, 95%CI: 1.18-2.84), lack of physical exercise(OR=2.25, 95%CI:1.65-3.07), diabetes(OR=2.29, 95%CI:1.32-3.97), smoking(OR=3.53, 95%CI:2.28-5.47), malnutrition(OR=4.04, 95%CI: 2.13-7.68), body fat rate(OR=1.21, 95%CI:1.15-1.25) and poor education(OR=1.24, 95%CI:1.05-1.47). Conclusions Age, age>70, BMI<18.5 kg/m^(2), gender, lack of physical exercise, diabetes, smoking, malnutrition, body fat rate, low education level are the major influencing factors for sarcopenia.Therefore, disease intervention should be strengthened among individuals who are vulnerable to the disease.