罗沙司他与重组人促红细胞生成素治疗血液透析肾性贫血临床疗效的比较研究

Comparative study for clinical effect of roxadustat and recombinant human erythropoietin in the treatment of hemodialysis renal anemia

目的比较罗沙司他与重组人促红细胞生成素(EPO)治疗血液透析肾性贫血的临床疗效。方法选取开平市中心医院2017年6月—2019年10月收治的肾性贫血患者70例,随机分为对照组36例与观察组34例。对照组予以重组人EPO结合蔗糖铁注射剂治疗,观察组予以罗沙司他结合蔗糖铁注射剂治疗。比较2组临床疗效,治疗前后贫血相关指标[包括红细胞(RBC)、血红蛋白(Hb)、血细胞比容(Hct)]、铁代谢指标[包括血清铁蛋白(SF)、转铁蛋白饱和度(TSAT)、转铁蛋白(TRF)、铁调素(HePc)],并观察2组不良反应发生情况。结果观察组临床疗效优于对照组(P<0.05)。治疗前2组RBC、Hb、Hct、SF、TSAT、TRF比较,差异无统计学意义(P>0.05);治疗后观察组RBC、Hb、Hct、SF、TSAT、TRF高于对照组,HePc低于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论与重组人EPO比较,罗沙司他治疗血液透析肾性贫血的临床疗效更好,可更有效改善患者贫血和人体的铁代谢功能,且安全性较高。

Objective To compare the clinical effect of roxadustat and recombinant human erythropoietin(EPO) in the treatment of hemodialysis renal anemia.Methods A total of 70 cases of patients with hemodialysis renal anemia were selected from June 2017 to October 2019 in Kaiping Central Hospital,which were randomly divided into control group(36 cases) and observation group(34 cases).The control group was treated with recombinant human EPO combined with iron sucrose injection,the observation group was treated with roxadustat combined with iron sucrose injection.Clinical effect,anemia indexes(including RBC,Hb and Hct) and iron metabolism indexes(including SF,TSAT,TRF and HePc) before and after treatment were compared between the two groups,and the incidence of adverse reactions were observed.Results The clinical efficacy of the observation group was better than control group(P<0.05).Before treatment,there was no significant difference in RBC,Hb,Hct,SF,TSAT and TRF between the two groups(P>0.05);after treatment,the observation group of RBC,Hb,Hct,SF,TSAT and TRF were higher than control group,while HePc was lower than control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Compared with recombinant human EPO,roxadustat is more effective in the treatment of hemodialysis renal anemia,which can effectively improve anemia of patient and iron metabolism function of human body,and with high safety.