阿司匹林联合阿托伐他汀钙治疗脑血栓的临床疗效及其安全性

Clinical effect and the safety of aspirin combined with atorvastatin calcium in the treatment of cerebral thrombus

目的探讨阿司匹林联合阿托伐他汀钙治疗脑血栓的临床疗效及其安全性。方法选取淄博市市级机关医院2018年7月—2020年7月收治的脑血栓患者90例,按照掷硬币分组法分为对照组与观察组,各45例。对照组予以阿司匹林治疗,观察组予以阿托伐他汀钙治疗,2组均持续治疗1个月。比较2组临床疗效,治疗前后凝血功能指标[包括纤维蛋白原(Fbg)、血细胞比容(Hct)、D二聚体(D-D)]、脑动脉斑块面积、颈动脉内膜-中层厚度、日常生活能力量表(ADL)评分,并观察2组不良反应发生情况。结果观察组总有效率高于对照组(P<0.05)。治疗前2组Fbg、Hct、D-D比较,差异无统计学意义(P>0.05);治疗后观察组Fbg、Hct、D-D低于对照组(P<0.05)。治疗前2组脑动脉斑块面积、颈动脉内膜-中层厚度、ADL评分比较,差异无统计学意义(P>0.05);治疗后观察组脑动脉斑块面积、颈动脉内膜-中层厚度小于对照组,ADL评分高于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论阿司匹林联合阿托伐他汀钙治疗脑血栓的临床疗效确切,可有效改善患者凝血功能,提高生活自理能力,且安全性较高。

Objective To observe the clinical effect and the safety of aspirin combined with atorvastatin calcium in the treatment of cerebral thrombus.Methods A total of 90 cases of patients with cerebral thrombus were selected from July 2018 to July 2020 in Zibo Municipal Government Hospital,which were divided into control group and observation group according to coin toss grouping method.The control group was treated with aspirin,the observation group was treated with atorvastatin calcium tablets.Both groups were treated continuously for 1 month.Clinical efficacy,coagulation function indexes(including Fbg,Hct and D-D),cerebral artery plaque area,carotid intima-media thickness and ADL score before and after treatment were compared between the two groups,and the incidence of adverse reactions were observed.Results The total effective rate of observation group was higher than control group(P<0.05).Before treatment,there was no significant difference in Fbg,Hct and D-D between the two groups(P>0.05);after treatment,Fbg,Hct and D-D in observation group were lower than control group(P<0.05).Before treatment,there was no significant difference in cerebral artery plaque area,carotid intima-media thickness and ADL score between the two groups(P>0.05);after treatment,the observation group of cerebral artery plaque area,carotid intima-media thickness were smaller than control group, and ADL score was higher than control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Aspirin combined with atorvastatin calcium have an exact clinical effect for cerebral thrombus,which can effectively improve the coagulation function of patients and improve their self-care ability,and with high safety.