疼痛敏感性的评估及相关影响因素研究进展

Research advances in the evaluation and influencing factors of pain sensitivity

疼痛敏感性和疼痛诊疗密切相关,且具有明显的个体差异。文章介绍实验室定量感觉测试(Quantitative Sensory Testing,QST)以及疼痛敏感性调查问卷(Pain Sensitivity Questionnaire,PSQ)两种疼痛敏感性评估方法,通过测定冷、热、压力及机械痛等痛觉阈值或个体根据过往经验和/或主观想象对描述的不同类别疼痛强度进行评分以预测个体的疼痛敏感性,全面分析P2X受体和儿茶酚胺O甲基转移酶等多个基因的相互作用,以及焦虑、抑郁、性别、睡眠、年龄、饮食、BMI、种族、社会和医疗经历等疼痛敏感性的影响因素,以期能够准确评估个体的疼痛敏感性,为精准化镇痛治疗提供参考。

Pain sensitivity is closely related to pain diagnosis and treatment,and there are obvious individual differences.In this paper,Quantitative Sensory Testing(QST)and Pain Sensitivity Questionnaire(PSQ)were introduced to assess pain sensitivity,where the pain thresholds of cold,heat,pressure and mechanical pain are measured and/or different types of pain intensities are assessed based on previous experience or subjectively described,so as to predict the individual sensitivity to pain.A comprehensively analyzing P2X receptor and catechol⁃O⁃methyl⁃transferase and other gene interactions,anxiety,depression gender,sleep,age,diet,body mass index(BMI),ethnicity,social and medical experience and other factors affecting pain sensitivity was conducted in order to accurately assess individual pain sensitivity and provide reference for precise analgesic treatment.