孤独症谱系障碍生理功能异常的研究进展

Progress of physiological dysfunctions in autism spectrum disorder

孤独症谱系障碍是一组高度异质性的神经发育障碍性疾病,患者常存在不同的生理功能异常。文献报道最多的生理功能异常主要集中在四个方面,包括免疫失调/炎症、氧化应激、线粒体功能障碍和环境毒素暴露。该文综述了孤独症患者存在的四个方面生理异常的主要表现,旨在阐述各方面生理功能异常与孤独症的关系,为孤独症发病机制研究、治疗和预防策略提供线索。

Autism spectrum disorder(ASD)is a group of highly heterogeneous neurodevelopmental disorders with different kinds of physiological dysfunctions.Based on the literature reports,physiological dysfunctions of ASD mainly focus on four aspects,including immune dysregulation/inflammation,oxidative stress,mitochondrial dysfunction and environmental toxin exposure.This review focuses on the main manifestations of the four physiological abnormalities in patients with ASD,aiming to illustrate the relationship between various physiological abnormalities and autism,providing clues for the research,treatment and prevention strategies of ASD.