血吸虫病史及代谢综合征与老年人肾损伤的相关性研究

Correlation between schistosomiasis history and metabolic syndrome and renal function in the elderly

目的探讨老年人肾功能下降与血吸虫病史及代谢综合征(MS)的相关性。方法以上海市松江区洞泾镇社区3175名老年人为研究对象通过筛选后,分析肾相关指标与血吸虫病史及MS的相关性。结果共纳入2111名老年人,其中有血吸虫病史者1256例,1003例患有MS。血吸虫病史为蛋白尿(OR=0.41)、血尿(OR=0.34)、肾功能下降(OR=0.44)的危险因素。不同组分MS是蛋白尿(OR=2.22~2.27)及肾功能下降(OR=2.28~3.10)的风险因素。而MS与血尿无明显相关。老年人肾功能下降的危险因素还包括吸烟、饮酒、尿酸增高、贫血、高密度脂蛋白降低及血同型半胱氨酸增高。结论老年人蛋白尿及肾功能下降与血吸虫病史及MS相关,而血尿仅与血吸虫病史相关,提示有血吸虫病史及MS的老年人应在体检中注意肾脏相关指标。

Objective To find out the correlation between the renal function decrease and schistosomiasis history and metabolic syndrome(MS).Methods Data of elderly people from Dongjing Town Community was collected and analyzed the correlation between renal impairment and schistosomiasis history and MS.Results A total of 2111 elderly subjects were enrolled.The cases of schistosomiasis and MS were 1256 and 1003 respectively.Schistosomiasis history was the risk factor of proteinuria(OR=0.41),hematuria(OR=0.34)and decreased renal function(OR=0.44).MS was the risk factor of proteinuria(OR=2.22~2.27)and decreased renal function(OR=2.28~3.10).Risk factors of decreased renal function in the elderly also include smoking,drinking,high serum uric acid,anemia,low high-density lipoprotein and high blood homocysteine.Conclusion For elderly people in this community,proteinuria and decreased renal function are related to schistosomiasis history and MS,while hematuria is only related to schistosomiasis history.