乌鲁木齐某社区居民2013及2017年血清尿酸水平变化趋势分析

Trend analysis of serum uric acid levels at a community of Urumqi in 2013 and 2017

目的调查新疆乌鲁木齐某社区居民血清尿酸水平的变化趋势。方法利用2013年及2017年5月在乌鲁木齐某社区慢性代谢疾病流行病学调查的4129例数据,选取资料完整的年龄16~84岁居民共3744例,测收缩压、舒张压、腹围、身高、体重、计算BMI。空腹采集静脉血,测血尿酸、TC、TG、LDL-C、HDL-C水平。结果 (1)共纳入的2013年及2017年3744例受试者中尿酸水平分别为(291.59±78.04)μmol/L和(294.83±91.82)μmol/L,其中两年男性尿酸水平均高于女性(t=24.628,P <0.001、t=-13.197,P <0.001)。(2)2013及2017年分别有179例和289例受试者患有高尿酸血症,其中男性高尿酸血症受试者尿酸水平均高于女性高尿酸血症受试者(t=11.882,P <0.001、t=4.687,P <0.001)。(3)2013年及2017高尿酸血症的患病率为分别为9.96%和14.85%,其中男性高尿酸血症患病率分别为为14.81%和14.68%,女性高尿酸血症的患病率分别为7.68%和14.90%,2013年男女间高尿酸血症患病率差异有统计学意义(χ^(2)=22.151,P <0.001)。两年高尿酸血症的患病率随年龄呈上升趋势,不同年龄段间比较差异有统计学意义(χ^(2)=26.671,P <0.001,χ^(2)=21.776,P <0.001)结论新疆维吾尔自治区乌鲁木齐某社区高尿酸血症患病率有上升趋势,且男性高于女性。

Objective To investigate the changing trend of serum uric acid levels at a community in Urumqi of Xinjiang in 2013 and 2017. Methods According to the data from 4129 cases with high uric acid disease in a community of Urumqi in May 2013 and 2017,3744 patients aged between 16-84 years were selected. Blood pressure, waist circumference, Height, weight, body mass index(BMI)were measured and recorded. Fasting blood samples were collected to test serum uric acid and other biochemical indexes. Results(1)Among the 3744 subjects enrolled, the serum uric acid level were(291.59±78.04)μmol/L and(294.83±91.82)μmol/L, which were higher in males than those in females(t = 24.628, P < 0.001、t =-13.197, P < 0.001).(2)There were 179 and 289 subjects with hyperuricemia in2013 and 2017. The uric acid level of male hyperuricemia subjects was higher than that of female hyperuricemia patients(t = 11.882, P <0.001, t = 4.687, P < 0.001).(3)The prevalence of hyperuricemia in 2013 and 2017 was 9.96% and 14.85%, repectively. The prevalence of male hyperuricemia were 14.81% and 14.68%, while the prevalence of hyperuricemia in female were 7.68% and 14.90%. There was a statistical difference in the prevalence of hyperuricemia between men and women in 2013 (χ^(2)= 22.151, P < 0.001). The incidence rate in two years increased with age, and the difference were statistically significant (χ^(2)= 26.671, P < 0.001, χ^(2)= 21.776, P < 0.001).Conclusion The prevalence of hyperuricemia in a community of Urumqi in Xinjiang has an upward trend, and it was higher in males other than females.