翼状胬肉相关生物标志物的研究

Research on biomarkers of pterygium

翼状胬肉发病机制尚不完全清楚,这可能是术后复发率较高的主要原因。翼状胬肉相关生物标志物包括肿瘤抑制基因、凋亡/增生相关蛋白、生长因子、基质金属蛋白酶及其抑制剂、白细胞介素、热休克蛋白、紧密连接蛋白、细胞黏附分子、细胞外基质蛋白、病毒等,这些生物标志物之间存在着复杂的网络关系,无明确的主次之分,可单独或协同促进翼状胬肉的发生发展。有效调控这些生物标志物的表达,可能是预防、治疗和降低翼状胬肉术后复发率的重要方法。(国际眼科纵览,2021,45:251-256)

The exact pathogenesis of pterygium is not completely understood,which result in high recurrence rate after surgery.The biomarkers of pterygium include tumor suppressor genes,proliferation/apoptosis related proteins,growth factors,matrix metalloproteinases and tissue inhibitors of metalloproteinases,interleukins,heat shock proteins,tight junction proteins,cell adhesion molecules,extracellular matrix proteins and viruses.There is a complex network relationship between these biomarkers,and there is no clear distinction between primary and secondary,and they can promote the occurrence and development of pterygium individually or cooperatively.If the expression of these biomarkers is effectively regulated,it may be the fundamental method to prevent,treat and reduce the recurrence rate of pterygium surgery.(Int Rev Ophthalmol,2021,45:251-256)