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二十八烷醇在动物机体中的生理调控功能研究进展 被引量:4

Advances in the Physiological Regulation Function of Octacosanol in Animals
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摘要 二十八烷醇是一种天然存在的长链脂肪醇,在脂质代谢、凝血功能、能量代谢、炎症反应、运动机能、抗氧化能力和神经系统功能等多个生理过程中发挥调控作用,但其具体调控机制未完全阐明。本文综述了二十八烷醇在动物和人中的生理调控作用的研究进展,以期为进一步深入研究和开发相关药物或饲料添加剂研究提供参考。 Octacosanol is a natural long-chain fatty alcohol.To date,studies have shown that dietary octacosanol can regulate lipid metabolism,coagulation function,energy metabolism,inflammatory response,exercise function,antioxidant capacity and nervous system function of human and animals.However,the specific regulatory mechanisms of octacosanol remain unclear.In this review,we summarize the current research progress of octacosanol regulation as well as the unsolved problems.Hopefully this review can provide new perspectives for future investigations of octacosanol.
作者 刘楚丹 李红飞 聂佳伟 侯伟晓 谭成全 邓近平 张琳 印遇龙 LIU Chudan;LI Hongfei;NIE Jiawei;HOU Weixiao;TAN Chengquan;DENG Jinping;ZHANG Lin;YIN Yulong(Guangdong Provincial Key Laboratory of Animal Nutrition Control,National Engineering Research Center for Breeding Swine Industry,Institute of Subtropical Animal Nutrition and Feed,College of Animal Science,South China Agricultural University,Guangdong Guangzhou 510642,China;Institute of Subtropical Agriculture,Chinese Academy of Sciences,Hunan Changsha 410125,China)
出处 《中国畜牧杂志》 CAS 北大核心 2021年第7期48-53,共6页 Chinese Journal of Animal Science
基金 国家自然科学基金(31802068、31790411) 广东省自然科学基金(2018A030310145)。
关键词 二十八烷醇 天然营养成分 吸收和代谢 生理调控 Octacosanol Natural nutrient Absorption and metabolism Physiological function
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  • 1Hirsch E, Graybiel AM, Agid YA. Melanized dopaminergic neurons are differentially susceptible to degeneration Jn Parkinson's disease. Nature 1988; 334: 345-8.
  • 2Jenner P, Olanow CW. Oxidative stress and the pathogenesis of Parkinson's disease. Neurology 1996; 47: S161-70.
  • 3Sherer TB, Betarbet R, Greenamyre JT. Pathogenesis of Parkinson's disease. Curr Opin Investig Drugs 2001; 2: 657-62.
  • 4Blum D, Torch S, Lambeng N, Nissou M, Benabid AL, Sadoul R, et al. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog Neurobiol 2001; 65: 135-72.
  • 5Schober A. Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP. Cell Tissue Res 2004; 318: 215-24.
  • 6Lee R, Kermani P, Teng KK, Hempstead BL. Regulation of cell survival by secreted proneurotrophins. Science 2001; 294: 1945-8.
  • 7Nykjaer A, Lee R, Teng KK, Jansen P, Madsen P, Nielsen MS, et al. Sortilin is essential for proNGF-induced neuronal cell death. Nature 2004; 427: 843-8.
  • 8Harrin-on AW, Leiner B, Blechschmitt C, Arevalo JC, Lee R, Morl K, et al. Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury. Proc Natl Acad Sci U S A 2004; 101: 6226-30.
  • 9Teng HK, Teng KK, Lee R, Wright S, Tevar S, Almeida RD, et al. ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci 2005; 25: 5455-63.
  • 10Casaccia-Bonnefil P, Carter BD, Dobrowsky RT, Chao MV. Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature 1996; 383: 716-9.

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