Toll样受体在鼻咽癌中的研究进展

Research progress of Toll-like receptors in nasopharyngeal carcinoma

鼻咽癌是我国常见的头颈部恶性肿瘤之一。Toll样受体(Toll-like receptors,TLRs)在免疫细胞中激活,不仅可以介导免疫反应,发挥抗肿瘤的作用,还可以产生免疫抑制因子促进肿瘤的免疫逃逸。Toll样受体在肿瘤细胞中激活不仅可以促进肿瘤细胞的增殖侵袭、转移能力和多药耐药抵抗,还能使肿瘤细胞逃避免疫监视。本文就Toll样受体在鼻咽癌中的作用机制及研究进展进行综述。

Nasopharyngeal carcinoma is one of the most common cancers of the head and neck in China.Toll like receptors(TLRs)are activated in immune cells,which can not only mediate immune response and play an anti-tumor role,but also produce immunosuppressive factors to promote tumor immune escape.In addition to promoting the proliferation,invasion and metastasis of tumor cells and multidrug resistance,Toll like receptors activation in tumor cells also helps tumor cells to evade immune surveillance.In this review,we reviewed the research progress of TLRs in nasopharyngeal carcinoma.