摘要
鼻咽癌是我国常见的头颈部恶性肿瘤之一。Toll样受体(Toll-like receptors,TLRs)在免疫细胞中激活,不仅可以介导免疫反应,发挥抗肿瘤的作用,还可以产生免疫抑制因子促进肿瘤的免疫逃逸。Toll样受体在肿瘤细胞中激活不仅可以促进肿瘤细胞的增殖侵袭、转移能力和多药耐药抵抗,还能使肿瘤细胞逃避免疫监视。本文就Toll样受体在鼻咽癌中的作用机制及研究进展进行综述。
Nasopharyngeal carcinoma is one of the most common cancers of the head and neck in China.Toll like receptors(TLRs)are activated in immune cells,which can not only mediate immune response and play an anti-tumor role,but also produce immunosuppressive factors to promote tumor immune escape.In addition to promoting the proliferation,invasion and metastasis of tumor cells and multidrug resistance,Toll like receptors activation in tumor cells also helps tumor cells to evade immune surveillance.In this review,we reviewed the research progress of TLRs in nasopharyngeal carcinoma.
作者
王予
曹现宝
阚晓丽
WANG Yu;CAO Xianbao;KAN Xiaoli(Department of Otolaryngology,The First People's Hospital of Yunnan Province,Kunming Yunnan 650000,China;Kunming Medical University,Kunming Yunnan 650000,China;Department of Infection,The 920th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army,Kunming Yunnan 650000,China)
出处
《转化医学杂志》
2021年第3期187-190,共4页
Translational Medicine Journal
关键词
TOLL样受体
鼻咽癌
作用机制
Toll-like receptors(TLRs)
Nasopharyngeal carcinoma
Mechanism of Action