摘要
来源于tRNA的RNA片段(tRNA-derived Fragments,tRFs)是一种非编码RNA(non-coding RNA,ncRNA),长度约为14-35 nt。tRFs源自前体tRNA(Pre-tRNA)或成熟tRNA,有如下几种主要类型:tRF-1,tRF-2,tRF-3,tRF-5和i-tRF,其在生命进程中具有调节基因表达、抑制蛋白质翻译等作用机制,并且在肿瘤诊治中也可充当生物标志物、治疗靶点等。本文就tRFs的生物学功能及其在癌症中的研究进展进行系统的综述。
tRNA-derived fragments(tRFs)are non-coding RNA with a length of about 14-35 nt.tRFs are derived from precursor tRNA(pre-tRNA)or mature tRNA,and have the following main types:tRF-1,tRF-2,tRF-3,tRF-5 and i-tRF,which have the mechanisms of regulating gene expression and inhibiting protein translation in life process,and can also serve as biomarkers and therapeutic targets in tumor diagnosis and treatment.In this paper,the biological function of tRFs and its research progress in cancer were systematically reviewed.
作者
许琳枫
王显仪
柴彬淑
马中良
XU Linfeng;WANG Xianyi;CHAI Binshu;MA Zhongliang(Laboratory for Non-coding RNA&Cancer,School of Life Sciences,Shanghai University,Shanghai 200444,China)
出处
《转化医学杂志》
2021年第3期191-196,共6页
Translational Medicine Journal
基金
上海市科委“创新行动计划”资助(NO:20S11901300)。
