微毛血见愁地上部分的化学成分研究

Chemical constituents from the aerial part of Teucrium viscidum var.nepetoides

目的研究微毛血见愁(Teucrium viscidum var.nepetoides)地上部分的化学成分。方法利用硅胶柱色谱、RP-C8反相柱色谱、Sephadex LH-20凝胶柱色谱和半制备HPLC等色谱技术分离微毛血见愁地上部分乙酸乙酯萃取部位的化学成分,运用波谱分析技术鉴定化合物结构。结果从该种植物中分离鉴定了6个化合物,分别鉴定为teuflin(1)、teucvidin(2)、isoteuflin(3)、teuvincenone F(4)、22-dehydroclerosterol(5)和水杨酸(6),其中化合物1~3为克罗烷型二萜类化合物,化合物4为松香烷型二萜类化合物。结论6个化合物均为首次从该植物中分离得到。

Objective To determine the chemical constituents from the aerial part of Teucrium viscidum var.nepetoides.Methods The chemical constituents of the ethyl acetate extract from the aerial part of Teucrium viscidum var.nepetoides were separated by silica gel,RP-C8,Sephadex LH-20 column chromatography,and semi-preparative HPLC.The structures of the isolates were identified by spectral analysis.Results Six compounds were isolated from the aerial part of Teucrium viscidum var.nepetoides,and were identified as teuflin(1),teucvidin(2),isoteuflin(3),teuvincenone F(4),22-dehydroclerosterol(5),and salicylic acid(6).Compounds 1~3 were clerodane diterpenoids,and compound 4 was an abietane diterpenoid.Conclusion All the compounds have been isolated from the plant for the first time.