他莫昔芬的药理作用与临床研究新进展

Research progress in the pharmacological action and clinical studies of tamoxifen

他莫昔芬属于非甾体类雌激素类似物,临床上用于治疗雌激素受体阳性乳腺癌已有多年。他莫昔芬可在机体不同组织器官如肺部、肝脏、肾脏、骨骼肌中广泛分布,根据作用组织部位的不同,他莫昔芬具有多样化的生物效应并对多种疾病具有治疗作用。本文总结了近年来他莫昔芬治疗脑胶质瘤、杜氏肌营养不良、心血管系统疾病、双相障碍等疾病的分子机制及其临床研究进展,以期为他莫昔芬的临床合理应用提供参考。

Tamoxifen(TAM)is a nonsteroid estrogen analogue,which has been used in the treatment of estrogen receptor positive breast cancer for many years.TAM is widely distributed in different organs,such as the lung,liver,kidney and skeletal muscles.According to function on different parts of the tissue,TAM has various biological and therapeutic effects on various diseases.This paper summarized the clinical research of TAM in the treatment of glioblastoma,duchenne muscular dystrophy,cardiovascular diseases,and bipolar disorder in recent years,as well as the research progress in its molecular mechanism.This paper can provide reference for clinical rational application of TAM.