太极拳学习过程中的静息态脑功能活动局部一致性研究

Regional homogeneity of resting state brain functional activities during Tai Chi Chuan learning

目的运用静息态功能磁共振成像(resting-state function magnetic resonance imaging,rs-fMRI)探究太极拳零基础者在太极拳不同学习阶段的脑功能活动的局部一致性(regional homogeneity,ReHo)变化。材料与方法采用被试内设计,对18名太极拳零基础被试在太极拳学习初期(2周)和学习14周进行同样内容的静息态功能磁共振成像检查。然后分别计算前后两个不同时间点被试的全脑ReHo值并进行相关统计学分析。结果与太极拳学习2周比较,太极拳学习14周被试右侧梭状回的ReHo值显著增高,而右侧小脑和左侧顶上小叶的ReHo值显著降低(AlphaSim校正P<0.05);其中右侧小脑的ReHo的变化值与太极拳技能评分的变化值呈显著负相关(r=-0.507,P=0.032)。多元回归分析发现,太极拳学习2周被试的右侧颞中回、右侧前扣带回的ReHo值与太极拳技能评分的变化量呈显著正相关(r=0.908、0.818,P<0.01),而左侧枕下回及右侧颞上回的ReHo值与太极拳技能评分的变化量呈显著负相关(r=-0.474,P<0.05;r=-0.824,P<0.01)。结论研究结果表明,随着太极拳学习技能水平的提高,被试的静息态功能活动局部一致性变化,反映了相关脑区可塑性。另外,太极拳学习初期某些脑区的ReHo值对太极拳技能学习效果有一定的潜在预测作用。

Objective:To explore regional homogeneity(ReHo)changes during different learning stages of Tai Chi Chuan(TCC)by using resting-state function magnetic resonance imaging(rs-fMRI).Materials and Methods:Within-subject design,18 TCC novices were performed two repeatedly rs-fMRI at the beginning learning phase of TCC(2 weeks)and 14 weeks of TCC learning,respectively.Then the whole brain ReHo values of the subjects were calculated and the statistical analysis was conducted.Results:Compared with2 weeks of TCC learning,ReHo values of the right fusiform gyrus significantly increased,while ReHo values of the right cerebellum and left superior parietal lobule significantly decreased(P<0.05,AlphaSim corrected)at 14 weeks of TCC learning;and there was a significant negative correlation between the changed ReHo values in the right cerebellum and the increments of TCC skill scores(r=-0.507,P=0.032).Multiple regression analysis showed that,at 2 weeks of TCC learning,ReHo values of the right middle temporal gyrus and right anterior cingulate were positively correlated with the increments of TCC skill scores(r=0.908,0.818,P<0.01,respectively),while ReHo values of the left occipital gyrus and right superior temporal gyrus were negatively correlated with the increments of TCC skill scores(r=-0.474,P<0.05;r=-0.824,P<0.01,respctively).Conclusions:The results suggest that ReHo of resting state functional activities changed,along with TCC learning skills improvements,reflecting brain plasticity.In addition,the ReHo values of some brain regions in the early stage of TCC learning may possibly have potential role in predicting the learning effects of TCC skills.