摘要
A convenient synthetic protocol for the hexasubstituted benzene derivatives was successfully developed by DABCO promoted domino reaction of arylidene malononitrile with two molecules of dialkyl but-2-ynedioates.The domino reaction resulted in tetraalkyl 6-cyano-[1,1'-biphenyl]-2,3,4,5-tetracarboxylates in good to high yields.This formal[2+2+2]cycloaddition was believed to proceed with sequential nucleophilic addition.Michael addition,annulation and aromatization processes.
基金
This work was financially supported by the National Natural Science Foundation of China(No.21572196)
the Priority Academic Program Development of Jiangsu Higher Education Institutions.
