Egg white as a natural and safe biomaterial for enhanced cancer therapy

The last few decades have witnessed the eme rgence of a very large variety of engineered nanomaterials.However,it is far from to meet the growing clinical demand.Actually,nature itself is an excellent na notechnologist,and provides us with a range of wonderful materials,from inorganic particles found in non-life bodies to biofilms,like platelets,erythrocyte membranes,produced by many bacteria or cells.These nanomaterials are entirely natural,and not surprisingly,there is a growing interest in the development of natural nanoproducts.Native components-inspired biomaterials have gained considerable attention owing to their sa fety and functions.In this study,egg white was developed as drug carrier to load PTX by a green and simple one-pot method,and systematic characterization was completed.The results indicated that PTX@EW NPs possess excellent biocompatibility,enhanced tumor targeting capability,effectively reducing the toxic side effects of PTX.The obviously enhanced antitumor effect further confirmed EW was a highly prospective biomaterial in the nano-carrier industry.