同型半胱氨酸在继发性高血压诊断中的临床价值研究

Study on clinical value of homocysteine in the diagnosis of patients with secondary hypertension

目的分析同型半胱氨酸(Hcy)在继发性高血压诊断中的临床价值。方法选取80例继发性高血压患者作为研究组,另选取同期行健康体检的健康者80例作为对照组。比较两组血压、同型半胱氨酸水平及研究组不同程度血压患者的同型半胱氨酸水平。结果研究组患者的舒张压(98.28±4.66)mm Hg(1 mm Hg=0.133 kPa)、收缩压(169.55±11.72)mm Hg、同型半胱氨酸(54.02±12.51)μmol/L均明显高于对照组的(79.05±2.73)mm Hg、(116.39±4.76)mm Hg、(4.63±0.52)μmol/L,差异有统计学意义(P<0.05)。血压≥181/111 mm Hg患者的同型半胱氨酸水平高于161~180/101~110 mm Hg及141~160/91~100 mm Hg患者,且血压161~180/101~110 mm Hg患者的同型半胱氨酸水平高于141~160/91~100 mm Hg患者,差异有统计学意义(P<0.05)。结论继发性高血压患者的同型半胱氨酸水平较健康者更高,且血压越高的患者,同型半胱氨酸水平越高。因此同型半胱氨酸的检测可以帮助临床对是否发生继发性高血压,或者对其疾病的严重程度进行预估。

Objective To analyze the clinical value of homocysteine(Hcy)in the diagnosis of patients with secondary hypertension.Methods There were 80 patients with secondary hypertension selected as the research group,and another 80 healthy subjects as the control group.Comparison was made on blood pressure and homocysteine level between the two groups,and homocysteine levels of patients with different levels of blood pressure in the research group.Results The diastolic blood pressure(98.28±4.66)mm Hg(1 mm Hg=0.133 kPa),systolic blood pressure(169.55±11.72)mm Hg and homocysteine(54.02±12.51)μmol/L of the research group were obviously higher than(79.05±2.73)mm Hg,(116.39±4.76)mm Hg and(4.63±0.52)μmol/L of the control group,and the difference was statistically significant(P<0.05).The level of homocysteine in patients with blood pressure≥181/111 mm Hg was higher than that in patients with blood pressure 161-180/101-110 mm Hg and 141-160/91-100 mm Hg,and the level of homocysteine in patients with blood pressure 161-180/101-110 mm Hg was higher than that in patients with blood pressure 141-160/91-100 mm Hg.All the difference was statistically significant(P<0.05).Conclusion Patients with secondary hypertension have higher homocysteine levels than healthy people,and patients with higher blood pressure have higher homocysteine levels.Therefore,the detection of homocysteine can help to predict the occurrence of secondary hypertension or the severity of the disease.