摘要
目的对比卡孕栓不同给药方式对晚期妊娠引产中预防产后出血的有效性及安全性。方法选取2019年6月至2020年6月在聊城市人民医院东昌府院区进行晚期妊娠引产的产妇80例,采用随机数字表法分为A组和B组,各40例。A组年龄(27.89±4.74)岁,B组年龄(27.81±4.86)岁。两组产妇均在胎儿娩出后宫体注射催产素20 U,A组产妇在胎儿娩出后即刻舌下含服卡孕栓1 mg,B组产妇在胎儿娩出后即刻将卡孕栓1 mg置于直肠内;分析两组产妇预防产后出血的效果。结果A组和B组产妇产后2 h出血量[(130.22±51.14)ml比(128.56±55.85)ml]、24 h出血量[(314.02±67.44)ml比(309.88±71.47)ml]、血红蛋白下降量[(9.02±2.85)g/L比(8.89±2.91)g/L]及产后出血率[7.50%(3/40)比10.00%(4/40)]比较,差异均无统计学意义(均P>0.05)。两组产妇给药后血压、心率及产后42 d宫底高度、子宫体大小比较,差异均无统计学意义(均P>0.05)。A组总不良反应发生率12.50%(5/40),B组17.50%(7/40),差异无统计学意义(P>0.05)。结论卡孕栓直肠给药和舌下含服效果相似,均可有效预防产后出血,且安全性高。
Objective To explore the efficacies and safety of methyl carprost suppository by different administration methods in the prevention of postpartum hemorrhage in induced labor of women during the third trimester of pregnancy.Methods Eighty parturients taking induced labor at Dongchangfu Hospital,Liaocheng People's Hospital from June,2019 to June,2018 were divided into group A and group B by the random number table method,with 40 cases in each group.Group A were(27.89±4.74)years old.Group B were(27.81±4.86)years old.Both groups were injected 20 U oxytocin into their uteruses after delivery.Group A sublingually took 1 mg methyl carprost suppository immediately after the delivery.Group B placed 1 mg methyl carprost suppository in their rectums immediately after delivery.The effects of the prevention of postpartum hemorrhage in both groups were analyzed.Results There were no statistical differences in bleeding volumes 2 and 24 hours after delivery[(130.22±51.14)ml vs.(128.56±55.85)ml and(314.02±67.44)ml vs.(309.88±71.47)ml],decrease of hemoglobin[(9.02±2.85)g/L vs.(8.89±2.91)g/L],and postpartum bleeding rate[7.50%(3/40)vs.10.00%(4/40)]between group A and group B(all P>0.05).There were no statistical differences in blood pressure and heart rate after medication and height of uterine floor and uterine body size 42 d after delivery between the two groups(all P>0.05).The total incidence of adverse reactions was 12.50%(5/40)in group A and was 17.50%(7/40)in group B(P>0.05).Conclusion Both rectal and sublingual administrations of methyl carprost suppository are similarly effective and safe,and can effectively prevent postpartum hemorrhage.
作者
徐晓雯
李丙环
张庆迪
Xu Xiaowen;Li Binghuan;Zhang Qingdi(Department of Obstetrics,Dongchangfu Hospital,Liaocheng People's Hospital,Liaocheng 252000,China;Department of Pharmacy,Liaocheng Dongchangfu People's Hospital,Liaocheng 252000,China)
出处
《国际医药卫生导报》
2021年第13期1999-2002,共4页
International Medicine and Health Guidance News
关键词
卡孕栓
直肠给药
舌下含服
产后出血
安全性
Methyl carprost suppository
Rectal administration
Sublingual administration
Postpartum hemorrhage
Safety