基于子午流注理论茵陈蒿汤药浴联合神阙穴贴敷对新生儿黄疸的干预效果

Medicated bath with Yinchenhao decoction combined with Shenque acupoint plaster therapy based on midnight-noon ebb-flow theory for neonatal jaundice

目的分析基于子午流注理论茵陈蒿汤药浴联合神阙穴贴敷在新生儿黄疸的干预效果。方法以前瞻性随机对照研究思路,将本院产科2020年4月至7月出生的出现黄疸的70例新生儿分为对照组与研究组,每组35例。对照组患儿男20例,女15例,日龄(10.60±2.64)d;研究组患儿男16例,女19例,日龄(10.15±2.78)d。对照组于辰时(07:00-09:00)、巳时(09:00—11:00)以外的时间接受茵陈蒿汤药浴联合神阙穴贴敷治疗;研究组于辰时、巳时接受茵陈蒿汤药浴联合神阙穴贴敷治疗,疗程均为5 d。对比两组患儿治疗前后血清总胆红素(TBil)水平、疗效及治疗期间的摄奶量、排便次数、不良反应情况。结果研究组血清TBil水平治疗1 d后[(196.57±33.60)μmol/L比(237.33±37.24)μmol/L]、治疗3 d后[(124.39±28.55)μmol/L比(168.92±31.48)μmol/L]、治疗5 d后[(75.48±18.38)μmol/L比(93.52±26.33)μmol/L]均低于对照组同期,两组比较差异均有统计学意义(均P<0.01);研究组治疗后的疗效优于对照组,治疗总有效率高于对照组[88.57%(31/35)比68.57%(24/35)],差异有统计学意义(χ^(2)=4.158,P=0.041));治疗期间研究组患儿摄奶量[(346.80±46.80)ml/d比(319.35±39.72)ml/d]、排便次数[(3.37±0.53)次/d比(3.09±0.46)次/d]均高于对照组,差异均有统计学意义(均P<0.05);两组患儿的不良反应[11.43%(4/35)比14.29%(5/35)]比较差异无统计学意义(P>0.05)。结论以子午流注理论择时,采用茵陈蒿汤药浴联合神阙穴贴敷治疗新生儿黄疸,可提升血清TBil下降速度,提升治疗有效率、摄奶量及每日排便次数,不良反应轻微。

Objective To analyze the intervention efficacy of medicated bath with Yinchenhao decoction combined with Shenque acupoint plaster therapy based on midnight-noon ebb-flow theory for neonatal jaundice.Methods 70 cases of neonatal jaundice delivered at Department of Obstetrics of our hospital from April to July,2020 were randomly divided into a control group and a study group,with 35 cases in each group.There were 20 males and 15 females in the control group;they were(10.60±2.64)days old.There were 16 males and 19 females in the study group;they were(10.15±2.78)days old.The control group took medicated bath with Yinchenhao decoction combined with Shenque acupoint plaster therapy not from 7:00 to 11:00,and the study group from 7:00 to 11:00,for 5 days.The serum total bilirubin(TBiL)levels before and after the treatment,curative effects,and human milk intake volumes,defecation frequencies,and adverse reactions during the treatment period were compared between the two groups.Results The serum TBiL levels 1,3,and 5 days after the treatment in the study group were lower than those in the control group[(196.57±33.60)μmol/L vs.(237.33±37.24)μmol/L,(124.39±28.55)μmol/L vs.(168.92±31.48)μmol/L,and(75.48±18.38)μmol/L vs.(93.52±26.33)μmol/L;all P<0.01].After the treatment,the total effective rate in the study group was higher than that in the control group[88.57%(31/35)vs.68.57%(24/35);χ^(2)=4.158,P=0.041].During the treatment,the human milk intake volume and defecation frequency of the study group were higher than those of the control group[(346.80±46.80)ml/d vs.(319.35±39.72)ml/d and(3.37±0.53)times/d vs.(3.09±0.46)times/d;both P<0.05].The incidence of adverse reactions was 11.43%(4/35)in the study group,and was 14.29%(5/35)in the control group(P>0.05).Conclusions Medicated bath with Yinchenhao decoction combined with Shenque acupoint plaster therapy based on midnight-noon ebb-flow theory for neonatal jaundice can decrease their serum TBiL fast and improve the treatment efficacy,human milk intake,and defecation frequency,and the adverse reactions are mild.