RAGE基因多态性与冠状动脉粥样硬化性心脏病患者MHR比值和心率变异的相关性分析

Association of RAGE gene polymorphisms with MHR ratio and heart rate variability among patients with coronary heart disease

目的探讨晚期糖基化终产物受体(receptor of advanced glycation end products,RAGE)基因多态性与冠状动脉粥样硬化性心脏病(简称冠心病)患者单核细胞/高密度脂蛋白胆固醇比值(monocyte-to-HDL cholesterol ratio,MHR)和心率变异的相关性。方法以120名冠心病患者作为观察组,另选取同期健康体检人群120名作为对照组,分析两组以及不同严重程度患者的-429T>C、1704G>T、82G>S基因型及等位基因、MHR比值、心率变异性之间的差异,分析上述基因型与MHR比值和心率变异性的相关性。结果两组以及不同严重程度患者的RAGE基因82G>S多态性以及等位基因之间的差异有统计学意义(P<0.05)。与对照组和轻中度患者相比,观察组以及重度患者的单核细胞、总胆固醇、甘油三酯、低密度脂蛋白、MHR、低频功率显著偏高,高密度脂蛋白、NN间期标准差、RR间期平均值标准差、相邻RR间期差值、相邻RR间期差值>50 ms的心搏数占比、高频功率显著偏低。G-Gly-T、T-Gly-T、G-Ser-T、G-Gly-C的基因频率与NN间期标准差、RR间期平均值标准差、相邻RR间期差值、相邻RR间期差值>50 ms的心搏数占比、高频功率、MHR呈正相关,与低频功率呈负相关。结论冠心病患者的RAGE基因多态性与冠心病患者MHR比值和心率变异性的显著相关,可作为疾病诊断以及疗效评价的重要依据。

Objective To assess the association of polymorphisms of receptor of advanced glycation end products(RAGE)gene,monocyte tohigh-density lipoprotein cholesterol ratio(MHR)and variability of heart rate among patients with coronary heart disease(CHD).Methods 120 patients with CHD and 120 healthy individuals were respectively selected as the observation group and the control group.Allelic and genotypic differences of-429T>C,1704G>T,82G>S,MHR ratio and heart rate variability between the two groups and patients with different severity were analyzed.The correlation between their genotypes and MHR ratio and heart rate variability was analyzed.Results The 82G>S polymorphism of the RAGE gene and the allelic difference between the two groups and patients with different severity were statistically significant(P<0.05).Compared with the control group and patients with mild to moderate phenotype,monocyte,total cholesterol,triglyceride,low density lipoprotein,MHR,low frequency in the observation group and patients with severe symptoms were significantly higher,while their high density lipoprotein,standard deviation of NN intervals(SDNN),standard deviation average of NN intervals(SDANN),root mean square successive differences,percentage of differences exceeding 50 ms between adjacent normal number of intervals(PMN50),high frequency(HF)were significantly lower.The gene frequencies of G-Gly-T,T-Gly-T,G-Ser-T and G-Gly-C were correlated with SDNN,SDANN,rMSSD,PMN50,HF and MHR,but negatively correlated with low frequency.Conclusion Polymorphisms of the RAGE gene in patients with coronary heart disease are associated with the MHR ratio and heart rate variability,which can be used as markers for the diagnosis and efficacy evaluation.