唾液腺腺样囊性癌淋巴结转移相关的研究进展

Research progress on the lymph node metastasis of salivary adenoid cystic carcinoma

唾液腺腺样囊性癌(salivary adenoid cystic carcinoma, SACC)是一种常见的唾液腺恶性肿瘤,恶性度高,局部复发和远处转移是SACC患者常见的死亡原因。传统上认为淋巴结转移在SACC患者中并不常见,然而由于文献报道的转移发生率差别很大,SACC患者颈部治疗方案仍有争议,且SACC术中淋巴结清扫范围尚无统一标准。本文就唾液腺腺样囊性癌颈部淋巴结转移相关的临床病理学参数,治疗方案及相关分子标志物等情况作一综述,为临床上SACC淋巴结转移的早期发现和治疗方案提供参考。

Salivary adenoid cystic carcinoma(SACC) is one of the most common malignant tumors. High malignancy, local recurrence and distant metastasis are common causes of death among patients with SACC. Lymph node metastasis has traditionally been considered uncommon in patients with SACC. However, due to the great difference in the incidence of metastasis reported in the literature, the treatment of neck for patients with SACC still remains controversial and there is no uniform standard for the surgery scope of lymph node dissection. This paper aims to provide an overview of the research progress of clinical pathological features, treatment and molecular signature of cervical lymph node metastasis in salivary adenoid cystic carcinoma, hoping to provide theoretical basis for early detection and treatment of SACC lymph node metastasis.