复发性阿弗他溃疡心理因素生物标志物研究进展

Advances in the study of biomarkers for psychological factors in recurrent aphthous ulcer

复发性阿弗他溃疡(recurrent aphthous ulcer, RAU)是一种口腔黏膜常见的炎症性溃疡类疾病。据调查,人群中RAU的发病率高,且溃疡发作时灼痛明显,尤其是重型复发性阿弗他溃疡(major recurrent aphthous ulcer, MaRAU)发作时疼痛剧烈,严重影响着人们的日常工作和生活。RAU的病因和发病机制尚不清楚,心理因素对RAU的影响不容忽视。迄今为止,国内外关于心理因素对RAU的研究多倾向于主观量表的评估,对其客观生物标志物的研究较少。本文就近年来国内外RAU心理因素生物标志物的研究进展作一综述。

Recurrent aphthous ulcer(RAU) is a common oral mucosal inflammatory ulcer disease. Investigations find that RAU has a higher incidence in the population. The burning pain caused by ulcer attacks is obvious, especially when the major recurrent aphthous ulcer attacks, seriously affecting people’s daily work and life. The etiology and pathogenesis of RAU are still unknown, and the influence of psychological factors on RAU cannot be ignored. Up to now, domestic and foreign researches on psychological factors of RAU tend to focus on the evaluation of subjective scale, and there are few studies on its objective biomarkers. In this paper, we review the recent advances in studies on biomarkers of RAU psychological factors at home and abroad.