肌源性因子调控骨组织细胞的作用机制研究进展

Research progress on mechanism of myokines regulating bone tissue cells

目的综述骨骼肌分泌的多种肌源性因子对各种骨组织细胞的作用及机制。方法查阅近年来与肌源性因子及其调控各种骨组织细胞相关的研究文献,并进行综合分析。结果骨与骨骼肌在解剖学、遗传学和生理病理学上存在紧密联系。研究发现骨骼肌能够分泌多种肌源性因子调控BMSCs、成骨细胞、破骨细胞及骨细胞,这些因子在肌骨单元间彼此联系、相互影响,形成一种复杂的肌骨微环境,并在一定程度上对骨修复和重建产生积极影响。结论肌源性因子是影响骨组织细胞动态平衡的潜在靶点,深入研究其作用机制有助于肌骨疾病的防治。

Objective To review the effects and mechanisms of various myokines secreted by skeletal muscle on various bone tissue cells.Methods Literature related to myokines and their regulation of bone tissue cells was reviewed and analyzed comprehensively in recent years.Results Bone and skeletal muscle are important members of the motor system,and they are closely related in anatomy,genetics,and physiopathology.In recent years,it has been found that skeletal muscle can secrete a variety of myokines to regulate bone marrow mesenchymal stem cells,osteoblasts,osteoclasts,and bone cells;these factors mutual crosstalk between myoskeletal unit,contact each other and influence each other,forming a complex myoskeletal micro-environment,and to some extent,it has a positive impact on bone repair and reconstruction.Conclusion Myokines are potential targets for the dynamic balance of bone tissue cells.In-depth study of its mechanism is helpful to the prevention and treatment of myoskeletal diseases.