大承气汤加味辅助治疗重症急性胰腺炎患者的效果

Effect of modified Dachengqi Decoction on Patients with severe acute Pancreatitis

目的研究大承气汤加味治疗重症急性胰腺炎(SAP)的效果。方法选取河南省开封市人民医院2019年2月至2020年2月收治的SAP患者88例,按照治疗方法分为常规组与研究组,各44例。常规组采用西医常规治疗,研究组采用大承气汤加味辅助西医常规治疗。比较两组疗效,症状改善时间(腹痛缓解、胃肠减压、肠鸣音恢复),治疗前后急性生理与慢性健康评分(APACHEⅡ评分)、血清淀粉酶(AMS)水平、尿淀粉酶水平及血清炎症因子水平[C反应蛋白(CRP)、白细胞介素-6(IL-6)]。结果研究组治疗有效率(95.45%)显著高于常规组(79.55%);研究组腹痛缓解、胃肠减压、肠鸣音恢复时间均显著短于常规组;治疗后,研究组APACHEⅡ评分、血清、尿AMS、血清CRP、血清IL-6水平均显著低于常规组,差异均显著(P <0.05)。结论大承气汤加味治疗SAP疗效显著,能改善症状与病情程度,降低血清、尿淀粉酶水平,减轻炎症反应。

Objective To study the effect of modified dachengqi decoction on severe acute pancreatitis.Methods 88 patients with SAP admitted to Kaifeng People’s Hospital from February 2019 to February 2020 were divided into routine group and study group according to the treatment method,44 cases each.The routine group was treated with conventional Western medicine,and the research group was treated with modified dachengqi decoction.The effects,symptom improvement time(abdominal pain relief,gastrointestinal decompression,bowel sounds recovery),acute physiological and chronic health score(APACHE II score),serum amylase(AMS),urinary amylase,and serum inflammatory factors(CRP,IL-6)before and after treatment were compared among the two groups.Results The total effective rate(95.45%)of the study group was significantly higher than that of the routine group(79.55%);The recovery time of abdominal pain,gastrointestinal decompression and rumbling in the study group was significantly shorter than that in the control group;after treatment,APACHE II score,serum,Urine AMS,serum CRP,serum IL-6 levels in the study group were significantly lower than those in the control group(P<0.05).Conclusion Modified dachengqi decoction is effective in the treatment of SAP.It can improve the symptoms and the degree of disease,reduce the level of serum and urine amylase,and reduce the inflammatory reaction.