复方海蛇胶囊联合复方吡拉西坦脑蛋白水解物治疗阿尔兹海默症的效果研究

Effect of Compound Haishe capsule combined with compound piracetam Cerebroprotein hydrolysate on Alzheimer’s Disease

目的探讨复方海蛇胶囊联合复方吡拉西坦脑蛋白水解物治疗阿尔兹海默症(AD)的效果。方法选取商丘市第二人民医院2017年3月至2019年6月收治的87例AD患者为研究对象,根据随机信封法分为实验组(n=44)和对照组(n=43)。对照组使用复方吡拉西坦脑蛋白水解物治疗,实验组在对照组的基础上加用复方海蛇胶囊治疗,比较两组治疗前后血清相关指标水平[血清血管紧张素Ⅱ(AngⅡ)、白细胞介素-6(IL-6)、降钙素基因相关肽(CGRP)水平]、认知功能[简易智力状态检查量表(MMSE)评分]及生活质量[老年痴呆患者生活质量量表(QOL-AD)评分]。结果治疗前,两组的血清AngⅡ、IL-6、CGRP水平比较,差异无统计学意义(P>0.05);治疗后,实验组患者的血清AngⅡ、IL-6水平显著低于对照组,血清CGRP水平显著高于对照组(P<0.05)。治疗前,两组的MMSE、QOLAD评分比较,差异无统计学意义(P>0.05);治疗后,实验组患者的MMSE、QOL-AD评分显著高于对照组(P<0.05)。结论复方海蛇胶囊联合复方吡拉西坦脑蛋白水解物治疗AD,可改善认知功能,保护脑神经,提高患者生活质量。

Objective To explore the effect of compound haishe capsule combined with compound piracetam cerebroprotein hydrolysate in the treatment of Alzheimer’s disease(AD).Methods A total of 87 patients with AD from March 2017 to June 2019 in the second people’s Hospital of Shangqiu were divided into experimental group(N=44)and control group(N=43)according to the random envelope method.The control group was treated with compound piracetam cerebroprotein hydrolysate,and the experimental group was treated with compound haishe capsule on the basis of the control group,the levels of serum Angiotensinogen II(Ang II),IL6(IL-6),Calcitonin Gene Related Peptide(CGRP),mini mental state examination(MMSE)and quality of life scale(QOL-AD)before and after treatment were compared between the two groups.Results Before treatment,the levels of Ang II,IL-6 and CGRP in the serum of the two groups were not significantly different(P>0.05).After treatment,the levels of Ang II and IL-6 in the experimental group were significantly lower than those in the control group,the level of CGRP in serum was significantly higher than that in control group(P<0.05).There was no significant difference in MMSE and QOL-AD scores between the two groups before treatment(P>0.05).After treatment,the MMSE and QOL-AD scores of the experimental group were significantly higher than those of the control group(P<0.05).Conclusion Compound haishe capsule combined with compound piracetam cerebroprotein hydrolysate in the treatment of AD can improve cognitive function,protect cerebral nerves and improve patient quality of life.