碳青霉烯类抗菌药物使用强度与耐药革兰阴性杆菌检出率的相关性

Correlation between the intensity of carbapenems and the detection rate of Gram-negative bacilli

目的分析合肥市第三人民医院住院患者碳青霉烯类抗菌药物使用强度(AUD)与耐碳青霉烯类革兰阴性杆菌(CRO)检出率之间的相关性,为临床合理用药和控制细菌耐药提供参考依据。方法统计该院2014年1月至2019年12月碳青霉烯类AUD及CRO检出率,采用SPSS 20.0统计软件对其进行Spearman相关性分析。结果AUD总体呈逐年增长趋势。6年间,耐碳青霉烯类鲍曼不动杆菌(CRAB)、铜绿假单胞菌(CRPA)、大肠埃希菌(CREC)及肺炎克雷伯菌(CRKP)的平均检出率分别为36.4%、13.4%、1.1%和14.0%。CRPA检出率与美罗培南的使用强度呈高度正相关(r=0.829,P=0.042);CRKP检出率与美罗培南及其他碳青霉烯类AUD呈高度正相关(r=0.943,P=0.005;r=0.829,P=0.042);CRAB和CREC检出率与碳青霉烯类AUD无相关性。结论碳青霉烯类AUD与CRPA、CRKP检出率具有相关性,应加强碳青霉烯类抗菌药物的使用管理,以延缓细菌耐药。LI Ming-zhen1,XU Peng1,CHEN Wei2,JIN Liang1,DENG Qian11.Department of Pharmacy 2.Microbiology Laboratory,the Third People's Hospital of Hefei,Hefei Third Clinical College of Anhui Medical University,Hefei 230022,China摘要图/表参考文献相关文章(2)全文:PDF(509 KB)HTML输出:BibTeX|EndNote(RIS)摘要目的分析合肥市第三人民医院住院患者碳青霉烯类抗菌药物使用强度(AUD)与耐碳青霉烯类革兰阴性杆菌(CRO)检出率之间的相关性,为临床合理用药和控制细菌耐药提供参考依据。方法统计该院2014年1月至2019年12月碳青霉烯类AUD及CRO检出率,采用SPSS 20.0统计软件对其进行Spearman相关性分析。结果AUD总体呈逐年增长趋势。6年间,耐碳青霉烯类鲍曼不动杆菌(CRAB)、铜绿假单胞菌(CRPA)、大肠埃希菌(CREC)及肺炎克雷伯菌(CRKP)的平均检出率分别为36.4%、13.4%、1.1%和14.0%。CRPA检出率与美罗培南的使用强度呈高度正相关(r=0.829,P=0.042);CRKP检出率与美罗培南及其他碳青霉烯类AUD呈高度正相关(r=0.943,P=0.005;r=0.829,P=0.042);CRAB和CREC检出率与碳青霉烯类AUD无相关性。结论碳青霉烯类AUD与CRPA、CRKP检出率具有相关性,应加强碳青霉烯类抗菌药物的使用管理,以延缓细菌耐药。

Objective To analyze the relationship between the detection rate of carbapenems resistant Gram-negative bacilli and the intensity of carbapenems antibacterial use in the inpatients of the Third People’s Hospital of Hefei,and to provide reference for rational drug use and control of bacterial resistance in clinical practice. Methods The use intensity of carbapenem antibiotics and the detection rate of Gram-negative bacilli resistant to carbapenem antibiotics in the hospital were analyzed from January 2014 to December 2019,and SPSS 20. 0 statistical software was used to conduct Spearman correlation analysis.Results The use intensity of carbapenems was increasing year by year. The average detection rates of carbapenem-resistant Acinetobacter baumannii(CRAB),carbapenem-resistant Pseudomonas aeruginosa(CRPA),carbapenem-resistant Escherichia coli(CREC)and carbapenem-resistant Klebsiella pneumoniae(CRKP)were 36. 4%,13. 4%,1. 1% and 14. 0%,respectively,in 6 years. The detection rate of CRPA was highly positively correlated with the use intensity of Meropenem(r=0. 829,P=0. 042). The detection rate of CRKP was highly positively correlated with the use intensity of Meropenem and carbapenems(r=0. 943,P=0. 005;r=0. 829,P=0. 042);the detection rates of CRAB and CREC were not correlated with carbapenems intensity.Conclusion The use intensity of carbapenems antibacterial agents is correlated with the detection rate of CRPA and CRKP to a certain extent. The use management of carbapenems antibacterial agents should be strengthened in order to delay bacterial resistance.