摘要
表观遗传学改变与肿瘤发生、发展和转归密切相关,在肿瘤精准及微创诊疗方面具有很好的应用潜力。DNA甲基化、羟甲基化与组蛋白修饰检测技术的进步,推动了基于表观遗传标志的液体活检研究的开展,在实体肿瘤的溯源定位、早期诊断、临床分期、疗效评价、复发监测及预后判断方面均取得了重要进展。
Epigenetic changes are closely related to carcinogenesis,tumor progression and prognosis,which have a considerable potential in assisting the precision and minimally invasive management of cancers.The progress of detection techniques for DNA methylation,hydroxymethylation and histone modification has promoted the research works of liquid biopsy targeting epigenetic markers,and recently,important progress has been made in tumor location,early diagnosis,clinical staging,evaluation of treatment response,monitoring of recurrence and prognostic prediction of solid tumors.
作者
庄伟涛
乔贵宾
Zhuang Weitao;Qiao Guibin(Department of Thoracic Surgery,Guangdong Provincial People′s Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China;Shantou University Medical College,Shantou 515041,China)
出处
《国际肿瘤学杂志》
CAS
2021年第6期358-361,共4页
Journal of International Oncology
基金
广东省科技创新战略专项(2020A1414070007)。