卡波西肉瘤相关疱疹病毒与宿主免疫在卡波西肉瘤发病中的作用机制及免疫治疗

Mechanism and immunotherapy of Kaposi sarcoma-associated herpesvirus and host immunity in the pathogenesis of Kaposi sarcoma

卡波西肉瘤是一种软组织多发性色素性血管瘤,其病因尚不明确,其发生发展与卡波西肉瘤相关疱疹病毒相关。卡波西肉瘤相关疱疹病毒可通过干扰模式识别受体、补体系统或直接作用于免疫细胞逃避宿主免疫系统,从而在卡波西肉瘤的发生与发展中起重要作用,免疫调节剂、靶向药物及疫苗等免疫治疗有望成为预防及治疗卡波西肉瘤的新方法。

Kaposi sarcoma is a multiple pigmented hemangioma of soft tissue.The etiology of Kaposi sarcoma is still unclear.Its occurrence is related to Kaposi sarcoma-related herpesvirus.Kaposi sarcoma-associated herpes virus plays an important role in the occurrence and development of Kaposi sarcoma by interfering with the pattern recognition receptors,complement system,or effecting on the immune cells directly to evasive host immune system.The immune modulators,immunotherapy of targeted drugs and vaccines are expected to be the new methods for the prevention and treatment of Kaposi sarcoma.